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Optical fiber conduction multi-detector discrete spectrum and fluorescent lifetime detection method and sensor

A technology of fluorescence lifetime and detection method, applied in fluorescence/phosphorescence, material analysis by optical means, instruments, etc., can solve the problems of inconvenient in-situ detection, short fluorescence lifetime, unable to capture fluorescence information, etc., to improve identification Speed ​​and identification accuracy, convenient hand-held operation, and the effect of improving identification accuracy

Inactive Publication Date: 2019-08-16
杨佳苗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, most of the fluorescence detection instruments currently on the market use cameras to detect fluorescence information of different wavelengths, which has problems such as low sensitivity and inconvenient use.
Especially when measuring the autofluorescence lifetime of the substance to be tested, the fluorescence signal excited by each pulse is extremely weak, and the fluorescence lifetime is also extremely short, so the spectral detection instruments based on the camera to measure the fluorescence information cannot capture such weak and short-lived fluorescence information
Moreover, in the detection process, it is usually necessary to remove the substance to be tested and put it into the instrument for detection, which is inconvenient for in-situ detection and the detection process is also very complicated

Method used

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  • Optical fiber conduction multi-detector discrete spectrum and fluorescent lifetime detection method and sensor
  • Optical fiber conduction multi-detector discrete spectrum and fluorescent lifetime detection method and sensor
  • Optical fiber conduction multi-detector discrete spectrum and fluorescent lifetime detection method and sensor

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Embodiment 1

[0033] The problem to be solved in this embodiment is to identify whether the white powdery substance to be tested is heroin or flour. In this embodiment, four photomultiplier tubes are used as light intensity detectors to respectively detect the fluorescence signals of four wavelengths of 400nm, 450nm, 530nm and 580nm excited from the substance to be measured, and according to the measured fluorescence lifetime and different The relative fluorescence intensity spectrum information between the wavelengths is used to identify the composition of the analyte. In this embodiment will be attached as figure 1 and 5 The shown optical fiber conduction multi-detector discrete spectrum and fluorescence lifetime detection method and sensor are implemented as attached Figure 8 For the device shown, the steps for identifying the components of the substance to be tested are as follows.

[0034] (a) A pulsed laser is emitted from the pulsed laser light source 1, the wavelength of the pu...

Embodiment 2

[0041] Different from Example 1, as attached figure 2 As shown, in order to improve the collection efficiency of fluorescence, fiber bundle 12 is used to replace excitation fiber 2 and collection fiber 4, one of the fibers in fiber bundle 12 is used as excitation fiber to transmit pulsed laser light, and the other six fibers in fiber bundle are used to transmit pulsed laser light. As a collection fiber, it collects the fluorescence excited from the substance to be measured. The six optical fibers are combined at the end after being transmitted, and the collected fluorescence enters the spectroscopic system 5 after being combined.

Embodiment 3

[0043] Different from Example 1, as attached image 3 As shown, the excitation fiber 2, collection fiber 4 and spectroscopic system 5 are replaced with fiber bundle 12, one of the optical fibers in the fiber bundle 12 is used as the excitation fiber to transmit pulsed laser light, and the remaining four fibers in the fiber bundle are used as collection The optical fiber collects the fluorescence excited from the substance to be measured, and separates the four optical fibers after transmission. Fluorescence transmitted from the four optical fibers is respectively passed through four filters to obtain four channels of fluorescence with different wavelengths.

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Abstract

The invention belongs to the technical field of chemical substance detection, and can be used for high-sensitivity detection and identification of chemical components of substances. A pulse laser is guided and excited fluorescence is transmitted by employing an optical fiber or an optical fiber bundle so that an operator can hold an optical fiber probe to flexibly detect a substance to be detected; and moreover, a plurality of detectors are employed to detect the fluorescent lifetimes and the spectral information under different wavelengths to perform high-sensitivity detection for the weak autofluorescence spectrum and the fluorescent lifetime, the detection precision is high, and the detection speed is fast. Therefore, the optical fiber conduction multi-detector discrete spectrum and fluorescent lifetime detection method and sensor provide a feasible way to the high-sensitivity and convenient measurement of the fluorescence lifetime and the fluorescence spectrum of the substance to be measured, and have important application in the research fields of biology, medicine, material science and the like and the clinical medicine diagnosis.

Description

technical field [0001] The invention belongs to the technical field of chemical substance detection, can be used for high-sensitivity detection and identification of chemical components of substances, and will have important applications in research fields such as biology, medicine, material science and clinical medical diagnosis. Background technique [0002] In the fields of biology, physics, chemistry and materials, spectral detection and analysis has become a basic measurement method for basic research due to its very high sensitivity, molecular specificity and non-contact measurement characteristics. In the industry, spectral detection and analysis have been widely used in the composition detection of various pollutants, food composition detection, industrial raw material composition detection, petroleum crude oil composition detection and so on. In the medical field, fluorescence spectroscopy and fluorescence microscopy provide a new direction for real-time imaging and...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 杨佳苗龚雷
Owner 杨佳苗
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