Fibroin/cellulose derivative composite material and preparation method thereof

A technology of cellulose derivatives and silk protein, which is applied in the field of high-strength natural biomacromolecular composite materials and its preparation, can solve the problems of unreachable mechanical properties and large-area human body defects, achieve good biodegradability, and promote network development. Sophisticated, Intensive and Controlled Effects

Inactive Publication Date: 2019-08-20
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In general applications, regenerated silk protein solutions are often used to prepare hydrogels, but their mechanical properties cannot meet the requirements of large-area human body defects or tissues with high mechanical properties.

Method used

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  • Fibroin/cellulose derivative composite material and preparation method thereof
  • Fibroin/cellulose derivative composite material and preparation method thereof
  • Fibroin/cellulose derivative composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take 9.5 mL of mulberry silk protein solution with a mass fraction of 10 wt%, add 0.5 mL of 10 wt% hydroxypropyl methylcellulose aqueous solution, mix evenly, and then heat in a water bath at 60°C for 1 hour to form a gel. Then soak it in 75% ethanol solution for 24 hours to obtain a high-strength silk protein-based hydrogel, and then dry it in an open environment for 48 hours to obtain a high-strength silk protein-based composite material. The compressive modulus reaches 719MPa. Tests show that it has stable performance and good cell compatibility under simulated in vivo environmental conditions.

Embodiment 2

[0039] Take 18 mL of tussah silk protein solution with a mass fraction of 5 wt%, add 2 mL of 5 wt% hydroxypropyl methylcellulose aqueous solution, mix well, and then heat in a water bath at 70°C for 2 hours to form a gel. Then soak it in 80% methanol solution for 24 hours to obtain a high-strength silk protein-based hydrogel, and then place it in an inner vacuum drying oven for 24 hours to obtain a high-strength silk protein-based composite material. The compressive modulus reaches 556MPa. Tests show that it has stable performance and good cell compatibility under simulated in vivo environmental conditions.

Embodiment 3

[0041]Take 18 mL of mulberry silk protein solution with a mass fraction of 20 wt%, add 2 mL of 20 wt% hydroxypropyl cellulose aqueous solution, mix evenly, and then heat in a water bath at 80°C for 0.5 hours to form a gel. Then it was soaked in 0.5M sodium lauryl sulfate solution for 48 hours to obtain a high-strength silk protein-based hydrogel, and then placed in a fume hood for 24 hours to obtain a high-strength silk protein-based composite material. The compressive modulus reaches 1603MPa. Tests show that it has stable performance and good cell compatibility under simulated in vivo environmental conditions.

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Abstract

The invention belongs to the technical field of natural polymer materials, and particularly relates to a fibroin / cellulose derivative composite material and a preparation method thereof. The preparation method comprises the steps: heating a mixed aqueous solution of a fibroin aqueous solution and hydroxypropylmethylcellulose or hydroxypropylcellulose or methylcellulose for curing, then immersingthe cured material in a solution which can induce transformation of fibroin for ageing, and performing drying so as to prepare the high-strength fibroin bulk material. The preparation process is simple, green and mild, energy-saving and efficient, has low cost, and the mechanical properties of the final bulk material can be controlled through simple adjustment of the solid content and blending ratio; and the prepared natural macromolecular-based high-strength material can be applied to the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of natural macromolecular materials, and in particular relates to a high-strength natural biological macromolecular composite material and a preparation method thereof. Background technique [0002] Tissue engineering has developed rapidly in recent years. Therefore, the use and preparation technology of biomedical materials with controllable properties, excellent biocompatibility and environmental friendliness in this field have attracted extensive attention. However, the existing natural polymer materials such as hydrogels, porous scaffolds, etc. are often difficult to meet the mechanical properties of large-scale injuries, such as bone cracks and fractures. The high-strength materials on the market are mainly autologous bone, various metals, bioceramics or polymers represented by polylactic acid. But these materials have their own limitations. For example, autologous bone transplantation is often accomp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L1/28C08J9/28
CPCC08J9/28C08J2389/00C08J2401/28C08L1/28C08L89/00C08L1/284
Inventor 邵正中宓瑞信董涛陈新刘也卓
Owner FUDAN UNIV
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