Patch and preparation method thereof
A patch and microneedle array technology, applied in pharmaceutical formulations, other medical devices, cosmetic preparations, etc., can solve the problems of easy separation of microneedles from the skin, affecting drug release, small size of microneedles, etc. Dosing rate and bioavailability, improving dosing rate, improving compliance
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Embodiment 1
[0095] This embodiment provides a patch for the treatment of rheumatoid arthritis, the size of the patch is 20mm × 20mm × 1.5mm, containing an isolation layer, the thickness of the isolation layer is 0.5mm; the number of microneedles is 100, in the form of figure 1 The shown 10×10 square matrix arrangement; the shape of the microneedles is conical, the needle length is 800 microns, the diameter of the needle base is 300 microns, and the distance between the microneedle bases is 600 microns.
[0096] The preparation method of above-mentioned patch is as follows:
[0097] 1. At room temperature, add hyaluronic acid into water for injection, stir to dissolve, then add melittin to obtain microneedle liquid, in the microneedle liquid, the mass concentration of hyaluronic acid is 30%, and the mass concentration of melittin The mass concentration is 11.1%.
[0098] 2. Prepare an ethanol solution of polyvinylpyrrolidone with a mass concentration of 25%, which is the isolation layer s...
Embodiment 2
[0106] This embodiment provides a patch for the treatment of rheumatoid arthritis, the size of the patch is 20mm×20mm×1.5mm, and does not contain an isolation layer; the number of microneedles is 100, arranged in a square matrix of 10×10; the microneedles The shape is conical, the length of the needle is 800 microns, the diameter of the base of the needle is 300 microns, and the distance between the bases of the microneedles is 600 microns.
[0107] The preparation method of above-mentioned patch is as follows:
[0108]1. At room temperature, dissolve an appropriate amount of melittin, trehalose, and chondroitin sulfate in water for injection, stir and dissolve, and swell fully to obtain a microneedle liquid. In the microneedle liquid, the mass concentration of melittin is 10%. , the mass concentration of trehalose is 1%, and the mass concentration of chondroitin sulfate is 20%.
[0109] 2. Weigh the prescription amount of sodium diclofenac, dissolve it completely in ethanol,...
Embodiment 3
[0114] This embodiment provides a patch for the treatment of melanosis diseases, the patch is a circular patch with a diameter of 14mm, without an isolation layer; the number of microneedles is 89, showing Figure 7 Circular arrangement shown; the shape of the microneedles is conical, the needle length is 500 microns, the diameter of the needle base is 200 microns, and the distance between the microneedle bases is 400 microns.
[0115] The preparation method of above-mentioned patch is as follows:
[0116] 1. At room temperature, add vitamin C to water for injection, stir to dissolve, then add hyaluronic acid to obtain a microneedle solution, in which the mass concentration of vitamin C is 0.75%, and the total drug loading is 240 μg , the mass concentration of hyaluronic acid is 30%.
[0117] 2, take by weighing the arbutin of prescription quantity, dissolve completely in propylene glycol, then add penetration enhancer azone, polymethacrylic resin pressure-sensitive adhesive,...
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Abstract
Description
Claims
Application Information
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