Continuous chromatographic device and panax notoginseng saponin production method

Abstract

The invention provides a continuous chromatographic device and a panax notoginseng saponin production method. The continuous chromatographic device comprises a sample feeding area, a water washing area, a low alcohol impurity removal area, a medium alcohol analysis area, a high alcohol regeneration area, a backwashing area, an anti-penetration area and a balance area which are sequentially and circularly arranged; each functional area is provided with a functional station; a plurality of chromatographic columns are respectively arranged on the functional stations; all the chromatographic columns are connected with a logic control valve; and the logic control valve is used for controlling all the chromatographic columns to move relatively to the eight functional areas, so that each chromatographic column circularly passes through all the functional stations in the eight functional areas in sequence, and function transformation of the chromatographic columns and continuous circulation operation are further realized. The resin columns on all the stations sequentially pass through the eight functional areas through valve switching, so that continuous loading, continuous separation andcontinuous collection of high-purity products during chromatographic separation are realized, and continuous automatic large-scale chromatographic treatment is realized.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine separation, in particular to a continuous chromatographic device and a production method of Panax notoginseng saponins. Background technique [0002] Panax notoginseng is a perennial herb of Araliaceae. The main root and rhizome of Panax notoginseng are rich in saponins, which have the functions of promoting blood circulation and removing blood stasis, dredging channels and collaterals, increasing cerebral blood flow, inhibiting platelet aggregation, improving microcirculation, and reducing blood viscosity. active. The total saponins of Panax notoginseng are mainly Panax notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ginsenoside Rd, high-content Panax notoginseng total saponins products (the content of five kinds of saponins is more than 85%) have been widely used in traditional Chinese medicine For injection, the common Sanqi total saponins injection p...

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Problems solved by technology

[0003] The conventional production process of Panax notoginseng saponins mostly adopts column chromatography and a combination of other methods: CN200510014846.1 Soak Panax notoginseng in water, add cellulose enzymolysis, anion exchange resin and macroporous resin to obtain Panax notoginseng total saponins The content is about 80%; CN201510396277.5 provides a method of combining ultrafiltration and nanofiltration technology with traditional extraction. Repeated ultrafiltration and nanofiltration to intercept low-molecular impurities such as polymers and inorganic salts can indeed improve the total The content of saponins, however, this method restricts its industrial application due to the uncontrollable membrane flux and the small amount of single treatment; CN201410706818.5 provides a kind of ethanol extraction, macroporous resin separation to increase the total saponin content of Panax notoginseng to 95% The above method, although the production process can obtain the product of Panax notoginseng saponins with higher content, it still stays at the laboratory level, and cannot realize the continuous and large-scale production of industrialization

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