Paeoniflorin molecularly imprinted polymer as well as preparation and application thereof
A technology of molecular imprinting and paeoniflorin, applied in ion exchange, other chemical processes, ion exchange regeneration, etc., can solve problems such as few literature studies, and achieve the effect of easy large-scale production and high purity
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[0017] Example 1
[0018] 1. Preparation of paeoniflorin molecularly imprinted polymer
[0019] (1) Prepare paeoniflorin molecularly imprinted polymer by sol-gel method. The specific process is as follows: Weigh 200g of spherical silica gel with a particle size of about 50μm, disperse it in 10ml of absolute ethanol, and then add 3ml (1.56mmol) of the crosslinking agent TEOS , Functional monomers APTES (0.86mmol) and PTMOS (1.0mmol) each 200μL, after shaking at room temperature for 30min, add 0.1mol / L paeoniflorin (0.08mmol) ethanol solution 800μL, double distilled water 1ml, 100μL concentrated HCl (concentration 36 %), react at room temperature for 4 hours, and filter to obtain 5.6 g of filter cake. The filter cake was washed three times with absolute ethanol and dried at 60°C, and then the filter cake was eluted with methanol-acetic acid (9:1, v / v) to remove the template molecules in the polymer until the washing solution had no UV absorption at 230nm. The imprinted polymer was ...
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[0024] Example 2
[0025] 1. Preparation of paeoniflorin molecularly imprinted polymer
[0026] (1) Prepare paeoniflorin molecularly imprinted polymer by sol-gel method. The specific process is as follows: Weigh 200g of spherical silica gel with a particle size of about 50μm, disperse it in 10ml of absolute ethanol, and add 6ml (3.12mmol) of the crosslinking agent TEOS , Functional monomers APTESl (1.72mmol) and PTMOS (2.0mmol) 400μL each, shake at room temperature for 30min, add 0.1mol / L paeoniflorin (0.16mmol) ethanol solution 1.6mL, double distilled water 1ml, 200μL concentrated HCl, room temperature After reacting for 4 hours, 3.3 g of product was obtained. The product was washed three times with absolute ethanol and dried. Then use methanol-acetic acid (9:1v / v) to elute the template molecules in the polymer until the washing solution has no UV absorption at 230nm. Wash the imprinted polymer with methanol three times to remove residual acetic acid, and finally at 60℃ After v...
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[0029] Example 3
[0030] 1. Preparation of paeoniflorin molecularly imprinted polymer
[0031] (1) Prepare paeoniflorin molecularly imprinted polymer by sol-gel method. The specific process is as follows: weigh 200g of spherical silica gel with a particle size of about 50μm, disperse it in 10ml of absolute ethanol, and add 1.5ml (0.78) of crosslinking agent TEOS mmol), functional monomers APTES1 (0.43mmol) and PTMOS (0.5mmol) each 100μL, shake at room temperature for 30min, add 0.1mol / L paeoniflorin (0.04mmol) ethanol solution 400μL, double distilled water 1ml, 50μL concentrated HCl, React at room temperature for 4 hours to obtain 4.4 g of product. The product was washed three times with absolute ethanol and dried. Then methanol-acetic acid (9:1v / v) was used to elute the template molecules in the polymer until the washing solution had no UV absorption at 230nm. The imprinted polymer was washed three times with methanol to remove residual acetic acid, and finally dried under vac...
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