Method for pure fermentation of medicated leaven by Pediococcus pentosaceus

A pure-species fermentation technology of Pediococcus pentosaceae, which can be applied to pharmaceutical formulations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., and can solve problems such as excessive bacteria and quality impact of Liushenqu, Achieve good smell, promote gastric emptying, excellent gastric emptying effect

Pending Publication Date: 2019-09-06
四川辅正药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the fermentation of Liushenqu is traditional natural fermentation, and there are many bacteria in the fermentation samples, and different environments will also have a great impact on the quality of Liushenqu

Method used

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  • Method for pure fermentation of medicated leaven by Pediococcus pentosaceus
  • Method for pure fermentation of medicated leaven by Pediococcus pentosaceus
  • Method for pure fermentation of medicated leaven by Pediococcus pentosaceus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 Liushenqu purebred fermentation method of the present invention

[0045] 1. Preparation of soft material (curly material)

[0046] Mix 1.5g bitter almonds and 1.5g red bean, pass through a No. 2 sieve and crush into a coarse powder, mix with 30g flour and 55g wheat bran, then divide into 250mL jars, seal with kraft paper, and sterilize at 121°C for 20min .

[0047] Take 4g cocklebur, 4g Artemisia annua, 4g Polygonum caperica, add 12 times the amount of water, soak for 30 minutes, decoct for 1 hour, filter with a 200-mesh filter cloth, and concentrate the filtrate into a clear paste (6.5 times the amount of the original drug) water), sterilized at 121°C for 20min.

[0048] The above-mentioned sterilized raw materials are allowed to cool under an ultraviolet lamp, and then fully mixed to obtain a soft material.

[0049] 2. Fermentation

[0050] Under sterile conditions, take 10ml concentration of 3 × 10 6 Cells / mL of Pediococcus pentosaceae suspension, m...

Embodiment 2

[0051] Embodiment 2 Liushenqu purebred fermentation method of the present invention

[0052] 1. Preparation of soft material (curly material)

[0053] Mix 1g of bitter almonds and 1g of red bean, pass through a No. 2 sieve and crush into a coarse powder, mix with 25g of flour and 50g of wheat bran, then divide into 250mL jars, seal with kraft paper, and sterilize at 121°C for 20 minutes.

[0054] Take 5g cocklebur, 5g Artemisia annua, 5g Polygonum caperica, add 12 times the amount of water, soak for 30 minutes, decoct for 1 hour, filter with a 200-mesh filter cloth, and concentrate the filtrate into a clear paste (6.5 times the amount of the original drug) water), sterilized at 121°C for 20min.

[0055] The above-mentioned sterilized raw materials are allowed to cool under an ultraviolet lamp, and then fully mixed to obtain a soft material.

[0056] 2. Fermentation

[0057] Under sterile conditions, take 10ml concentration of 2 × 10 6 Cells / mL of Pediococcus pentosaceae su...

Embodiment 3

[0058] Embodiment 3 Liushenqu purebred fermentation method of the present invention

[0059] 1. Preparation of soft material (curly material)

[0060] Mix 0.5g bitter almonds and 0.5g red bean, pass through a No. 2 sieve and crush into a coarse powder, mix with 20g flour and 45g wheat bran, then divide into 250mL jars, seal with kraft paper, and sterilize at 121°C for 20min .

[0061] Take 6g of cocklebur, 4g of Artemisia annua, 5g of Polygonum caperica, add 12 times the amount of water, soak for 30 minutes, decoct for 1 hour, filter with a 200-mesh filter cloth, and concentrate the filtrate into a clear paste (6.5 times the amount of the original drug) water), sterilized at 121°C for 20min.

[0062] The above-mentioned sterilized raw materials are allowed to cool under an ultraviolet lamp, and then fully mixed to obtain a soft material.

[0063] 2. Fermentation

[0064] Under sterile conditions, take 10ml with a concentration of 0.82×10 6 Cell / mL Pediococcus pentosaceae ...

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Abstract

The invention provides a method for pure fermentation of medicated leaven. The method comprises the steps of inoculating Pediococcus pentosaceus into raw materials required by traditional medicated leaven fermentation, and fermenting. The raw materials required by the traditional medicated leaven fermentation need to be sterilized at high temperature of 100 DEG C or above. The invention also provides a medicated leaven product obtained by the method. The medicated leaven disclosed by the invention has excellent capability of promoting gastric emptying. The effect is better than that of medicated leaven obtained by natural fermentation, and is also higher than that of medicated leaven obtained by pure fermentation of bacillus subtilis, Absidia corymbifera, aspergillus flavus and aspergillusniger.

Description

technical field [0001] The invention relates to the field of processing traditional Chinese medicine Liushenqu. Background technique [0002] Liushenqu is a traditional Chinese medicine, which is prepared by fermenting Polygonum, Artemisia annua, Cocklebur, Chixiaodou, Bitter Almond, Wheat Bran and Flour. Liushenqu has the functions of invigorating the spleen and harmonizing the stomach, and regulating the indigestion; it is used for weak spleen and stomach, stagnant diet, chest distension and abdominal distension, and food accumulation in children. [0003] At present, the fermentation of Liushenqu is traditional natural fermentation, and there are many bacteria in the fermentation samples, and different environments will also have a great impact on the quality of Liushenqu. Contents of the invention [0004] The purpose of the invention is to provide a method for pure fermentation of Liushenqu. [0005] Technical scheme of the present invention comprises: [0006] A p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/14
CPCA61K36/28A61K36/282A61K36/48A61K36/704A61K36/736A61K36/899A61K2236/19A61P1/14A61K2300/00
Inventor 孙继林姚仁川陈美华景秀萍张红玲张晓瑞
Owner 四川辅正药业股份有限公司
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