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Application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or/and rhinitis

A technology of cannabidiol and milk preparations, which is applied in the biological field to achieve the effects of low recurrence rate, enhanced drug efficacy, and no toxic and side effects

Inactive Publication Date: 2019-09-24
云南辰锦威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the effects of treating epilepsy (CN103826621A), brain tumor (CN102083426B), mental illness (CN101939017B), etc., but there is no literature report on the effect of treating rhinitis

Method used

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  • Application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or/and rhinitis
  • Application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or/and rhinitis
  • Application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or/and rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Prepare raw materials according to the following mass percentages:

[0032]

[0033] (2) Put the sweet orange oil in a 30°C water bath and heat it for 20 minutes. After the temperature of the sweet orange oil reaches 30°C, add cannabidiol to the sweet orange oil. After the phenol is completely dissolved, place it at room temperature to obtain material A;

[0034] (3) Add fatty alcohol polyoxyethylene ether, PEG-400, and sorbitol to material A and mix evenly, then add part of water, stir the mixture at a speed of 10 r / s until completely dissolved, and obtain material B;

[0035] (4) Refrigerate material B at 3°C ​​for 15 hours, filter, collect the filtrate, and obtain material C;

[0036] (5) Add potassium sorbate to the material C to adjust the pH value to 5, and then add the rest of the water to stir and mix to obtain the cannabidiol CBD nanoemulsion spray.

Embodiment 2

[0038] (2) Prepare raw materials according to the following mass percentages:

[0039]

[0040]

[0041] (2) Put the sweet orange oil in a 67°C water bath and heat it for 10 minutes. After the temperature of the sweet orange oil reaches 67°C, add cannabidiol to the sweet orange oil. After the phenol is completely dissolved, place it at room temperature to obtain material A;

[0042] (3) Add fatty alcohol polyoxyethylene ether, PEG-400, and sorbitol to material A and mix evenly, then add some water, stir the mixture at a speed of 40 r / s until completely dissolved, and obtain material B;

[0043] (4) Refrigerate material B at 5°C for 10 hours, filter, collect the filtrate, and obtain material C;

[0044] (5) Add potassium sorbate to the material C to adjust the pH value to 6, and then add the rest of the water to stir and mix to obtain the cannabidiol CBD nanoemulsion spray.

Embodiment 3

[0046] (3) Prepare raw materials according to the following mass percentages:

[0047]

[0048] (2) Put the sweet orange oil in a water bath at 30-67°C and heat it for 15 minutes. After the temperature of the sweet orange oil reaches 45°C, add cannabidiol to the sweet orange oil. After the cannabidiol is completely dissolved, place it at room temperature to obtain material A;

[0049] (3) Add fatty alcohol polyoxyethylene ether, PEG-400, and sorbitol to material A and mix evenly, then add some water, stir the mixture at a speed of 20 r / s until completely dissolved, and obtain material B;

[0050] (4) Refrigerate material B at 4°C for 12 hours, filter, collect the filtrate, and obtain material C;

[0051] (5) Add potassium sorbate to the material C to adjust the pH value to 5, then add the rest of the water, stir and mix well, and obtain the cannabidiol-containing CBD nanoemulsion smear.

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Abstract

The invention discloses an application of cannabidiol CBD and nanometer milk thereof to preparations for urticaria or / and rhinitis. The cannabidiol CBD nanometer milk preparation is prepared from the following raw materials in mass ratio of 5-20% of cannabidiol CBD, 1-10% of fatty alcohol polyoxyethylene ether, 1-5% of PEG-400, 1-5% of sorbitol, 1-10% of sweet orange oil, 0.02-0.1% of potassium sorbate and the balance water, wherein the sum of the components is 100%. The cannabidiol CBD nanometer milk preparation can rapidly restrain symptoms of acute and chronic urticaria, acute and chronic rhinitis and nasosinusitis, cannot cause skin sensibility, is free from toxic and side effects, and is obvious in treatment effects. The effective component namely the cannabidiol CBD and the nanometer milk thereof, is an effective preparation being free from side effects and low in recurrence rate, through combination of the preparation of the nanometer milk, the drug effect is further reinforced, and the problems that when a conventional drug is used for treating the urticaria and the rhinitis, repeated attack is easy to cause, and skin sensibility is easy to cause, and the conventional drug is short in quality guarantee period and instable in drug effects, can be solved.

Description

technical field [0001] The invention relates to the application of cannabidiol CBD and its nanoemulsion in the preparation of urticaria or / and rhinitis medicine, belonging to the field of biotechnology. Background technique [0002] Urticaria, known as addiction rash in traditional Chinese medicine, is a skin, mucous membrane or vascular reactive allergic disease caused by complex etiology. The types of urticaria include: cold urticaria, protein allergic urticaria, skin scratch rash, papular urticaria, allergic urticaria, cholinergic urticaria, acute urticaria, chronic urticaria, etc. The main clinical manifestations are , First, the skin feels itchy, and after scratching, red wheals appear on the skin. This red wheal comes and goes quickly, and can disappear by itself without leaving any traces after subsiding, but the condition is prone to repeated attacks. Due to changes in environmental factors, the number of patients suffering from urticaria is increasing day by day, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/12A61K31/05A61K47/10A61K47/26A61K47/44A61P11/02A61P17/00A61P37/08
CPCA61K9/1075A61K9/12A61K31/05A61K47/10A61K47/26A61K47/44A61P11/02A61P17/00A61P37/08
Inventor 李映波冯红农春秋孙笠雯罗凡雅
Owner 云南辰锦威生物科技有限公司
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