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Preparation method of medical biodegradable polymer material polylactate geycollic acid

A polyglycolide and polymer material technology, applied in the field of medicine, can solve the problems of difficult preparation and purification of rare earth compounds, poor reaction controllability, unsuitable copolymerization, etc., and achieves reduction of molecular weight distribution index, short reaction time, The effect of improving purity

Active Publication Date: 2019-09-27
SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are certain shortcomings in the above catalyst systems. For example, tin salt catalytic initiator systems generally trigger high-temperature bulk copolymerization, high degree of side reactions such as transesterification, and poor reaction controllability; the reaction speed of organoaluminum compounds is too fast, and a large amount of heat is released in a short period of time. Not suitable for bulk copolymerization; the preparation and purification of rare earth compounds are difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of polyglycolide (PLGA), a biodegradable polymer material for medical use, comprising the following steps:

[0032] Weigh 110g of lactide monomer (LA) and 90g of glycolide monomer (GA), pour it into a three-necked flask, weigh 0.04g of tetraphenyltin (the molar ratio of lactide monomer to 8000), n-butyl Alcohol (lactide monomer and its molar ratio is 500), mix the catalyst and the initiator and inject it into the three-necked flask, install the nitrogen conduit, mercury thermometer, stirrer, etc., feed nitrogen, start the stirring device, and make sure the system is sealed. Then heat up, control the temperature of the liquid in the three-necked flask at 190-280°C, and the reaction pressure is 0.07-0.08MPa. After 4-16 hours of reaction, the product is discharged. The product color is light yellow. The crude product is dissolved in chloroform and precipitated with ether three times. Vacuum drying to constant weight is the finished product. The molecu...

Embodiment 2

[0034] A preparation method of polyglycolide (PLGA), a biodegradable polymer material for medical use, comprising the following steps:

[0035] Weigh 110g lactide monomer (LA) and 90g glycolide monomer (GA), pour it into a three-necked flask, weigh 0.039g stannous octoate (lactide monomer and its molar ratio is 8000), n-butanol (Lactide monomer to its molar ratio is 500), mix the catalyst and the initiator and inject it into the three-necked flask, install the nitrogen conduit, mercury thermometer, stirrer, etc., feed nitrogen, start the stirring device, and confirm that the system is sealed. Raise the temperature, control the temperature of the liquid in the three-necked flask at 120-220°C, and the reaction pressure at 0.05-0.09MPa. After 5-13 hours of reaction, the color of the discharged product is light yellow. The crude product is dissolved in chloroform, precipitated with ether three times, vacuum Dry to constant weight to get the finished product. The molecular weight ...

Embodiment 3

[0037] A preparation method of polyglycolide (PLGA), a biodegradable polymer material for medical use, comprising the following steps:

[0038] Weigh 140g of lactide monomer (LA) and 60g of glycolide monomer (GA), pour it into a three-necked flask, weigh 0.039g of stannous octoate (the molar ratio of lactide monomer to 10000), n-butanol (Lactide monomer to its molar ratio is 500), mix the catalyst and the initiator and inject it into the three-necked flask, install the nitrogen conduit, mercury thermometer, stirrer, etc., feed nitrogen, start the stirring device, and confirm that the system is sealed. Raise the temperature, control the temperature of the liquid in the three-necked flask at 120-200°C, and the reaction pressure at 0.07-0.08MPa. After 4-11 hours of reaction, the product is discharged. The color of the product is light yellow. Add chloroform to dissolve, ether precipitate 3 times, and vacuum dry The finished product is obtained at constant weight. The molecular w...

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Abstract

The invention provides a preparation method of medical biodegradable polymer material polylactate geycollic acid (PLGA). A mass polymerization method is adopted for manufacturing the polylactate geycollic acid (PLGA), the production technology is simple, conditions needed by the reaction are low, the reaction speed is high, and the reaction time is short; a catalytic system adopting an organic metal compound as a main catalyst and adopting a substance containing reactive hydrogen as an initiator is adopted as an efficient catalytic system, the reaction time is shorter compared with a single catalyst, the weight-average molecular weight of the product is adjustable, the lowest molecular weight distribution index can reach 1.40, the catalytic activity is high, and the PLGA is non-toxic basically; the reaction product is precipitated three times, unreacted monomers and low-molecular-weight by-products can be removed, the molecular weight distribution index is lowered, and the product purity is improved.

Description

technical field [0001] The invention relates to a preparation method of polyethylene lactide, a biodegradable polymer material used in medicine, and belongs to the technical field of medicine. Background technique [0002] Polylactide (PLGA) is an important class of biomedical polymer materials, which combines the advantages of two polyester materials, polylactic acid (PLA) and polyglycolide (PGA), and has good biocompatibility and Degradability, the degradation products lactic acid and glycolic acid can participate in the metabolism of the human body, and finally form carbon dioxide and water to be excreted from the body. They are widely used in surgical sutures, fracture fixation, tissue repair, plastic surgery, anti-tissue adhesion, drug slow release, Tissue engineering and other biomedical fields. [0003] Polylactide (PLGA) is a random copolymerization, amorphous polymer, its glass transition temperature is between 40-60 ° C, different monomer ratios can prepare differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/83C08G63/85
CPCC08G63/08C08G63/823C08G63/83C08G63/85
Inventor 苏红清袁文博赵春华李建
Owner SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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