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Feilike capsule extract and application and quality control method thereof

A technology of capsules and extracts, which is applied in the field of quality control of Feilike capsule extracts, can solve the problems of inconsistent preparation methods, no quality identification standards, and low conversion rate of baicalin, so as to achieve simple extraction methods and control product quality , the effect of good product quality

Pending Publication Date: 2019-10-01
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of Feilike Capsule Extract is not uniform at present, and the conversion rate of baicalin is low. 21 h 18 o 11 ), less than 5mg, and there is no quality identification standard

Method used

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  • Feilike capsule extract and application and quality control method thereof
  • Feilike capsule extract and application and quality control method thereof
  • Feilike capsule extract and application and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, the preparation method of Feilike capsule extract

[0028] The preparation method of Feilike capsule extract, each component is composed as follows: 173g of Scutellaria baicalensis, 167g of Peucedanum, 160g of Baibu, 150g of gentian safflower, 130g of Wutong root, 96g of red pipe medicine, 120g of Hedyotis diffusa, including the following Steps: Scutellaria baicalensis is crushed through a 16mm sieve plate; then part of the baicalensis is crushed into a fine powder with a particle size of less than 80 mesh, and set aside. Decoct in boiling water for 2 hours, add boiling water equivalent to 6 times the weight of the medicinal material for the second time and decoct for 1.5 hours, combine the decoction, filter, and shrink the filtrate to a clear paste with a relative density of 1.17-1.20 (80°C), that is, The clear paste obtained is a brown extract. Every 1g of Scutellaria baicalensis contains baicalin (C 21 h 18 o 11), not less than 12mg. Adding boiling...

Embodiment 2

[0030] Embodiment 2, Feilike Capsule Extract Quality Control Method

[0031] (1) Baicalin identification: get 3 parts of the extractum prepared by the method of Example 1, each part of 2ml, add methanol 20ml, ultrasonic treatment for 20 minutes, filter, the filtrate is evaporated to dryness, and the residue is dissolved by adding methanol 5ml, as test product solution. Another appropriate amount of baicalin (batch number: 110715-201016, source: China Institute for the Control of Pharmaceutical and Biological Products) was taken as a reference substance, and methanol was added to make a solution containing 1 mg per 1 ml as the reference substance solution. And the extract of Scutellaria baicalensis was treated as the negative control solution according to the test sample. According to the test of thin-layer chromatography (Appendix VIB of "Chinese Pharmacopoeia" 2010 edition), draw 5-10 μl of each of the above two solutions, respectively spot on the same silica gel G thin-laye...

Embodiment 3

[0080] Example 3: Validation of efficacy of Feilike Capsules Extract

[0081] In order to prove the efficacy of Feilike Capsules Extract, experiments were carried out on Feilike Capsules Extract in terms of anti-oxidation, immunoglobulin concentration and bacteriostasis. The specific methods are as follows:

[0082] 120 mouse models of bacterial bronchopneumonia were randomly divided into treatment group, control group and positive control group. Treatment method: the treatment group took Feilike capsule extract, 125 mg each time, 3 times a day, for 2 weeks; the control group took the same amount of Feilike mixture disclosed in CN1415324A. Taking penicillin as positive control simultaneously, serum superoxide dismutase (SOD), lipid peroxide (LPO) is carried out to mouse before and after taking, and the detection result of immunoglobulin IgG, IgA, IgM is as shown in table 1 and table 2 Show.

[0083] Table 1. Changes of SOD and LPO before and after taking Feilike Capsules

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Abstract

The invention relates to a Feilike capsule extract and application and quality control method thereof. The Feilike capsule extract is prepared according to the following method that radix scutellariae, radix peucedani, radix stemonae, gentiana rhodantha Franch, firmiana roots, threevein aster and spreading hedyotis herb are taken according to a prescription; the radix scutellariae is smashed and sieved by a 16-millimeter sieve plate; then part of the radix stemonae is smashed into fine powder with a grain size smaller than 80 mesh for standby application, boiling water is added in the remaining radix stemonae and the other six medicinal materials for two times of decoction, for the first time, the boiling water with the weight equal to 8 times of the weight of the medicinal materials is added for the decoction for 2 hours, for the second time, the boiling water with the weight equal to 6 times of the weight of the medicinal materials is added for the decoction for 1.5 hours, decoctionsolutions are mixed, filtration is carried out, a filter liquor is subjected to deep concentration to obtain an extract with the relative density of 1.17-1.20(at 80 DEG C), and the Feilike capsule extract is obtained. The extract prepared by the method can fully retain the active ingredients and increase the content of the radix scutellariae. The invention also discloses the quality control methodof the Feilike capsule extract. The method can better control the product quality.

Description

technical field [0001] The invention belongs to the field of pharmacy, relates to a preparation method of Feilike capsule extract, and also relates to a quality control method of Feilike capsule extract. Background technique [0002] Respiratory disease is a common disease with a high incidence rate in the elderly and children. After the onset, it manifests as coughing, panting, poor breathing, and excessive phlegm. Some will stay up all night and affect the patient's health. It also endangers the patient's life. Feilike capsule extract is based on the prescription of 173g of Scutellaria baicalensis, 167g of Peucedanum, 160g of Baibu, 150g of gentian safflower, 130g of Wutong root, 96g of red pipe medicine, and 120g of Hedyotis diffusa. powder, and then extract and condense the remaining herb and other medicinal materials to obtain an extract, which has a good curative effect on the above diseases. However, the preparation method of Feilike Capsule Extract is not uniform a...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61P11/14G01N30/02
CPCA61K36/185A61K36/23A61K36/28A61K36/515A61K36/539A61K36/748A61K36/904A61K2236/331A61K2236/39A61K2236/51A61P11/14G01N30/02A61K2300/00
Inventor 孙小鸚廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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