Iodinated oil embolic agent easy to infuse and preparation method thereof

A technology of iodized oil and embolic agent, which is applied in the field of iodized oil embolic agent with high drug loading and its preparation, can solve the problems of difficult drug loading and difficulty in bolus injection of iodized oil, achieve stable structure, reduce viscosity, The effect of increasing solubility

Inactive Publication Date: 2019-10-08
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of embolism that is easy to inject and have high drug loading and its preparation method for the problems of difficult injection of iodized oil and difficult drug loading in the clinical application process.

Method used

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  • Iodinated oil embolic agent easy to infuse and preparation method thereof
  • Iodinated oil embolic agent easy to infuse and preparation method thereof
  • Iodinated oil embolic agent easy to infuse and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of antineoplastic drug-containing embolism

[0034] (1) Add 20 mg of paclitaxel to 150 mg of 1,2-propanediol, heat to 40°C, and stir magnetically for 20 minutes.

[0035] (2) Take 500 mg of iodized oil and 330 mg of Cremophor RH40 in a vial, place on a magnetic stirrer and stir at a stirring speed of 1200 rpm min -1 , stirring time is 40min.

[0036] (3) Mix the liquids in steps 1 and 2 and place them on a magnetic stirrer for stirring at a stirring speed of 1000rpm min -1 , the stirring time was 45min, and the temperature was maintained at 40°C. Finally, a light yellow homogeneous solution is obtained, which is the desired embolic agent. Dilute the embolic agent 5 to 10 times with water for injection before operation to obtain emulsion droplets with a particle size of 5 to 110 μm (such as figure 1 ), easy to inject. Transcatheter arterial embolization was performed on patients with liver cancer, and it was found that the imaging effect wa...

Embodiment 2

[0037] Embodiment 2: preparation containing antineoplastic drug embolism

[0038] (1) Add 30 mg of carmustine to 150 mg of medium-chain fatty acid glycerides, and stir on a magnetic stirrer at a speed of 600 rpm min -1 , the time is 50min, and the temperature is 45°C.

[0039] (2) Take 400 mg of iodized oil, 300 mg of Cremophor RH40 and 120 mg of PEG 400, add them into a vial, and stir on a magnetic stirrer at a speed of 1000 rpm min -1 , stirring time is 45min.

[0040] (3) After mixing the liquids in steps 1 and 2, stir on a magnetic stirrer at a speed of 800rpm min -1 , the stirring time was 60min, and a light yellow homogeneous liquid was obtained, which was the required embolism. Dilute the embolic agent 5 to 10 times with water for injection before operation to obtain emulsion droplets with a particle size of 50 to 400 μm (such as image 3 ), easy to inject. Transcatheter arterial embolization was performed on patients with liver cancer, and it was found that the im...

Embodiment 3

[0041] Embodiment 3: preparation containing antineoplastic drug embolism

[0042] (1) Take 450 mg of ethyl oleate and 30 mg of docetaxel in a vial, preheat to 45°C, and stir the vial on a magnetic stirrer at a speed of 500 rpm min -1 , the stirring time is 30min, so that docetaxel is fully dissolved in ethyl oleate.

[0043] (2) Add 520 mg of iodized oil to the above-mentioned ethyl oleate, and stir on a magnetic stirrer at a speed of 800 rpm min -1 , the stirring time was 45min, and a slightly pale yellow homogeneous oil solution was obtained. The oil solution is the required embolic agent. Due to the lower viscosity of ethyl oleate, the viscosity of the mixed solution is significantly lower than that of iodized oil. Before the operation, the embolic agent is artificially emulsified to form small droplets with a particle size of 100-300 μm, which are used to embolize the distal end of the arteriole.

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Abstract

The invention belongs to the field of medical diagnosis and interventional therapy, and relates to a high drug loading iodinated oil embolic agent easy to infuse and preparation method thereof. The iodinated oil embolic agent is provided for solving the existed problem that infusion and drug loading are not prone to conducting in iodinated oil embolization of clinical application, is prepared fromthe components of iodinated oil, oil for injection, emulgator and antineoplastic drug, and the functions of embolism, development and chemotherapy are achieved. According to the embolic agent, the oil for injection and the emulgator with low viscosity are introduced, the viscosity of the iodinated oil is greatly lowered, infusion is facilitated, the particle size of emulsion droplet after emulsification can be controlled by adjusting the ratio of the emulgator, and the structure is stable. According to the iodinated oil embolic agent, the oil for injection and the emulgator are used for increasing oil-soluble antineoplastic drug, water-soluble antineoplastic drug can also be increased through the method of forming a W / O emulsion, and preparation is simple and easy to conduct.

Description

technical field [0001] The invention belongs to the field of medical diagnosis and interventional therapy, and relates to a lipiodol embolic agent with high drug loading capacity which is easy to inject and a preparation method thereof. Background technique [0002] Malignant tumor is the second leading cause of human death and a serious threat to human health. Among them, the top five cancers that die from malignant tumors are: gastric cancer, liver cancer, lung cancer, esophageal cancer and colorectal cancer. At present, the main methods for the treatment of malignant tumors include surgery, radiotherapy, chemotherapy and interventional therapy. Transcatheter arterial embolization (TCAE) has been proven to be an effective non-surgical method for the treatment of solid tumors. It selectively injects embolic materials into the supply vessels of a diseased organ through a catheter, occludes the corresponding vessels, and interrupts the blood supply. achieve the purpose of tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00A61L31/16A61L31/18
CPCA61L31/005A61L31/16A61L31/18A61L2300/216A61L2300/416A61L2300/602
Inventor 张建斌赵艳艳马晓东田燕唐泽耀董佩佩刘静李斌崔虹霞
Owner DALIAN MEDICAL UNIVERSITY
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