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Multifunctional surface enhanced Raman substrate material, and preparation method and application thereof

A surface-enhanced Raman and substrate material technology, applied in Raman scattering, material analysis, material excitation analysis, etc., can solve the problems of Au nanoparticle loss, non-reusable, weak stability, etc., and achieve good signal consistency , easy operation, and the effect of improving detection sensitivity

Pending Publication Date: 2019-10-08
FOOD INSPECTION CENT OF CIQ SHENZHEN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For example, the patent application number is 201410168680.8, and the patent name is the invention patent of surface-enhanced Raman scattering active substrate and its preparation method, which realizes Au nanoparticles as the substrate, but it uses electrochemical deposition to deposit Au on the rough surface formed by etching Nanoparticles, poor encapsulation, easy to cause loss of Au nanoparticles, poor stability; patent application number is 201610721315.4, the patent name is the invention patent of preparation and application of three-dimensional surface enhanced Raman paper substrate, with high sensitivity and Selective, but because it uses wax printing technology to prepare paper substrates, grows flower-shaped silver in the working area, and realizes the "on-off" of surface-enhanced Raman signals through the etching reaction of reactants and silver, and cannot be reused

Method used

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  • Multifunctional surface enhanced Raman substrate material, and preparation method and application thereof
  • Multifunctional surface enhanced Raman substrate material, and preparation method and application thereof
  • Multifunctional surface enhanced Raman substrate material, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] (1) Preparation of AgNPs suspension:

[0044] 1. Thoroughly clean glassware with 68% nitric acid;

[0045] 2. Then add 10mL 0.3mM polyvinylpyrrolidone (PVP, Mw~8000) solution and 10mL 2.5% silver nitrate solution into the beaker, and keep it in the ice-water bath for 10 minutes;

[0046] 3. Then 10 mL of 20 mM sodium borohydride was added dropwise to the mixture and stirred for 1 hour to form a crude solution of AgNPs;

[0047] 4. The formed AgNPs were collected by centrifugation and washed with deionized water (DI);

[0048] 5. Then disperse the AgNPs in the aqueous solution to prepare a 1 mg / mL AgNPs suspension, and thoroughly disperse the nanoparticles by ultrasonic waves for 30 minutes;

[0049] (2) Nylon filter membrane pretreatment: pretreatment with oxygen, then with plasma cleaning for 2 minutes to remove surface impurity molecules;

[0050] (3) Vacuum filtration: Pour the AgNPs suspension into a cylindrical funnel, and separate the solid and liquid through a...

Embodiment 2

[0055] (1) Preparation of AgNPs suspension:

[0056] 1. Thoroughly clean glassware with 68% nitric acid;

[0057] 2. Then add 5mL 0.1mM polyvinylpyrrolidone (PVP, Mw~8000) solution and 5mL 2.5% silver nitrate solution into the beaker, and keep it in the ice-water bath for 10 minutes;

[0058] 3. Then 8 mL of 20 mM sodium borohydride was added dropwise to the mixture and stirred for 1.5 hours to form a crude solution of AgNPs;

[0059] 4. The formed AgNPs were collected by centrifugation and washed with deionized water (DI);

[0060] 5. Then disperse the AgNPs in the aqueous solution to prepare a 5 mg / mL AgNPs suspension, and thoroughly disperse the nanoparticles by ultrasonic waves for 30 minutes;

[0061] (2) Nylon filter membrane pretreatment: pretreatment with oxygen, then with plasma cleaning for 2 minutes to remove surface impurity molecules;

[0062] (3) Vacuum filtration: Pour the AgNPs suspension into a cylindrical funnel, and separate the solid and liquid through t...

Embodiment 3

[0065] (1) Preparation of AgNPs suspension:

[0066] 1. Thoroughly clean glassware with 68% nitric acid;

[0067] 2. Then add 8mL 0.2mM polyvinylpyrrolidone (PVP, Mw~8000) solution and 7mL 2.5% silver nitrate solution into the beaker, and keep it in the ice-water bath for 10 minutes;

[0068] 3. Then 5 mL of 20 mM sodium borohydride was added dropwise to the mixture and stirred for 2 hours to form a crude solution of AgNPs;

[0069] 4. The formed AgNPs were collected by centrifugation and washed with deionized water (DI);

[0070] 5. Then disperse the AgNPs in the aqueous solution to prepare a 3 mg / mL AgNPs suspension, and thoroughly disperse the nanoparticles by ultrasonic waves for 30 minutes;

[0071] (2) Nylon filter membrane pretreatment: pretreatment with oxygen, then with plasma cleaning for 2 minutes to remove surface impurity molecules;

[0072] (3) Vacuum filtration: Pour the AgNPs suspension into a cylindrical funnel, and separate the solid and liquid through the...

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Abstract

The invention discloses a multifunctional surface enhanced Raman substrate material, and a preparation method and an application thereof. The material is formed by combining a nylon filter membrane and nano-silver embedded into micropores of the nylon filter membrane. The preparation method comprises the following steps: (1) preparing AgNPs suspension liquid; (2) pretreating the nylon filter membrane: firstly carrying out pretreatment by using oxygen, and then carrying out cleaning by using plasmas; (3) preparing a multifunctional surface enhanced Raman substrate: carrying out solid-liquid separation on the AgNPs suspension liquid prepared in the step (1) in a vacuum suction filtration mode through the nylon filter membrane obtained in the step (2), then taking out the nylon filter membrane embedded with AgNPs, and carrying out air drying. The vacuum suction filtration method is adopted; the packaging performance is good, the stability is improved; the substrate distribution is uniform; the sensitivity is high; the signal consistency is good; the nylon filter membrane is adopted as a carrying material; the anti-friction performance is achieved; the material can be repeatedly used;the cost is low; and the preparation process is simple. Meanwhile, the multi-appearance and multi-function design is also suitable for practical application in the POCT field.

Description

technical field [0001] The invention relates to the field of surface-enhanced Raman base materials, in particular to a multifunctional surface-enhanced Raman base material and its preparation method and application. Background technique [0002] In recent years, miniaturized Raman spectroscopy and surface-enhanced Raman spectroscopy have developed rapidly, and their applications have been extended to the field of point-of-care testing (POCT), which is of great significance to the development of portable detection devices. Therefore, in the analysis and sensing system based on SERS Among them, it is very important to prepare SERS substrates with low cost and high performance. For more than a decade, scientists have realized several POCT applications of SERS substrates, such as template-assisted fabrication of nanostructures, self-assembly of nanocolloids for SERS active site preparation. However, for the real market, the technology is quite expensive and not suitable for ind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82Y30/00
CPCG01N21/658B82Y30/00
Inventor 陈波靳保辉赵旭梁培叶嘉明
Owner FOOD INSPECTION CENT OF CIQ SHENZHEN
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