A kind of bichiral central cyclopropylsilane compound and its preparation method and application

A technology of cyclopropylsilane and compound, which is applied in the field of chiral center cyclopropylsilane compound and its preparation, can solve the problems of restricted structure diversification and the like, achieves strong substrate universality, novel synthesis method and mild reaction conditions Effect
CN110317220BActive Publication Date: 2022-03-08HANGZHOU NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU NORMAL UNIVERSITY
Publication Date
2022-03-08

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Abstract

The invention relates to the field of chiral organosilanes, and specifically discloses a bichiral central cyclopropylsilane compound shown in formula (I) and a preparation method thereof, comprising: combining cyclopropene shown in formula (II) with diphenyl Cyclopropylsilane compounds with high yield and high enantioselectivity were efficiently synthesized by asymmetric hydrosilylation reaction of cyclopropylsilane. Compared with the traditional [2+1] cycloaddition and 1,3-cyclization substituted cyclopropylamino reactions, it is a more direct and effective method for the synthesis of cycloalkane compounds, and can obtain a variety of different compounds that cannot be prepared by traditional methods. Cyclopropylsilane compounds with substituents are widely used in the fields of materials chemistry and medicinal chemistry.
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Description

technical field

[0001] The invention relates to the field of chiral organosilanes, in particular to a bichiral central cyclopropylsilane compound and its preparation method and application. Background technique

[0002] Chiral organosilanes are gradually playing an important role in siliceous substitution in organic synthesis, materials science and medicinal chemistry, among which chiral silicon-containing organic compounds are very useful synthetic blocks in organic chemistry; silane-substituted compounds are due to their Low toxicity and favorable metabolic characteristics have attracted increasing attention in medicinal chemistry; chiral catalysts containing silicon atoms are also widely used in asymmetric organocatalysis. Silicon-based chiral compounds are important components for selective carbon-carbon bond formation, and the asymmetric hydrosilylation of alkenes provides a direct route to construct chiral organosilanes.

[0003] 3,3-Disubstituted cyclopropylsilanes a...

Claims

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