2-(2,2-diarylethyl)-cyclamine derivative or salt, and synthesis and application and composition thereof

Abstract

The invention provides 2-(2,2-diarylethyl)-cyclamine derivative or salt, and synthesis and application and a composition thereof. Biological activity testing shows that the 2-(2,2-diarylethyl)-cyclamine derivative has great M receptor antagonistic activity, and can serve as pharmaceutical active ingredients to be used for treating muscarinic receptor mediated or regulated diseases comprising asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm accompanied with COPD, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental illness, and the like.

Description

technical field

[0001] The invention relates to the field of pharmaceutical components for treating or preventing diseases related to M receptor antagonism, in particular to a 2-(2,2-diarylethyl)-cyclic amine derivative and a preparation method thereof. Background technique

[0002] Muscarinic acetylcholine receptors (M receptors) are widely distributed in smooth muscle, myocardium, central and peripheral nerve tissues and various glands, and are divided into five subtypes (M1-M5). Studies have shown that the occurrence and disease process of many major diseases, such as COPD, asthma, OAB, Parkinson's syndrome, etc., are closely related to the dysfunction of different subtypes of M receptors. Therefore, the study of M receptor antagonists has become one of the hot spots in pharmaceutical research.

[0003] 3,3-Diarylpropylamine derivatives are widely studied drug intermediates with M-receptor antagonism, and can be used to treat various neurological disorders related to M-r...

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