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Polyvinyl alcohol-heparin polymer as well as preparation method and application thereof

A polyvinyl alcohol and polymer technology, which is applied in the fields of polyvinyl alcohol-heparin polymer and its preparation, and anticoagulant implant materials, can solve the problem of lack of physiological anticoagulant substances, easily obstructed blood flow, life-threatening, etc. problems, to achieve the effects of excellent mechanical properties and biocompatibility, excellent structural stability, and good application prospects

Active Publication Date: 2019-10-25
SIBIKANG XIAMEN NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of stopping the infusion, on the one hand, the flexible tube can be regarded as a tube-in-tube in the blood vessel; The flow of blood at the indwelling hose is easily hindered, and may even coagulate to form emboli, which extend centripetally and even block organ veins, causing functional failure and threatening life
[0005] In recent years, in the actual clinical application of intravenous indwelling needles on the market, cases of rupture of the indwelling tube have been reported one after another. The broken indwelling tube remains in the blood vessel for a long time, which brings great safety hazards to patients.

Method used

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  • Polyvinyl alcohol-heparin polymer as well as preparation method and application thereof
  • Polyvinyl alcohol-heparin polymer as well as preparation method and application thereof
  • Polyvinyl alcohol-heparin polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0086] Preparation of spares

[0087] 3-Chloro-2-hydroxypropyltrimethylammonium chloride solution: add 600g of 3-chloro-2-hydroxypropyltrimethylammonium chloride to 2400g of ethylene glycol to fully dissolve, and set aside at room temperature;

[0088] Sodium hydroxide solution: add 30g of sodium hydroxide to 200g of deionized water to fully dissolve, and set aside at room temperature;

[0089] Triethylenediamine solution: add 450 grams of triethylenediamine to 2550 grams of deionized water to fully dissolve, and set aside at room temperature;

[0090] Heparin solution: add 20 grams of heparin to 880 grams of deionized water to disperse and dissolve, and set aside at room temperature;

[0091] 1M hydrochloric acid solution: measure 86.0mL of 36% hydrochloric acid, dilute to 1000mL with deionized water, and set aside at room temperature; 0.5M sulfuric acid solution: measure 27.2mL of 98% sulfuric acid, pour into appropriate amount of deionized water , and finally dilute to 10...

Embodiment 2-6

[0104] Embodiments 2-6 are all based on the method of Example 1, and the weight ratio (heparin addition amount) of polyvinyl alcohol to heparin, the polymerization degree and alcoholysis degree of polyvinyl alcohol, and the average molecular weight of heparin are adjusted, and the specific adjustment See Table 2 below for details.

[0105] The parameter table of polyvinyl alcohol and heparin in table two embodiment 1-6

[0106]

Embodiment 7-9

[0108] Examples 7-9 are all based on the method of Example 1, and the production process parameters of the polyvinyl alcohol-heparin polymer and the production process parameters of the indwelling hose are adjusted. For specific adjustments, see Table 3 below.

[0109] Table 3 The preparation process parameters of polyvinyl alcohol-heparin polymer and indwelling hose in Examples 7-9

[0110]

[0111] 2.4, Embodiment 10

[0112] In this example, on the basis of the method in Example 1, the preparation method of polyvinyl alcohol-heparin polymer is adjusted, and the original water-soluble method is changed to a melting method. Specifically include the following steps:

[0113] ① Melting of polyvinyl alcohol: Add polyvinyl alcohol into the stirring tank, stir evenly, add polyvinyl alcohol, heat up to 80°C, stir at a low speed of 50r / min until fully melted; the melting temperature can be set at Fluctuates between 75-85°C;

[0114] ②Modification of polyvinyl alcohol: Add 3-ch...

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Abstract

The invention relates to a biomedical material in the fields of medicine and medical instruments, in particular relates to an anticoagulation implant material, and in particular relates to a polyvinylalcohol-heparin polymer as well as a preparation method and application thereof. The polyvinyl alcohol-heparin polymer is formed by connecting polyvinyl alcohol and heparin through ionic bonds formedbetween the polyvinyl alcohol and the heparin, the polyvinyl alcohol is quaternary ammonium salt-modified cationic polyvinyl alcohol, and the modification conditions of the cationic polyvinyl alcoholare as follows: pH is 11.0-12.5, temperature is 50-55 DEG C, and reaction time is 4 h. The polyvinyl alcohol-heparin polymer provided by the present application can be used to process a soft and elastic indwelling hose, and the indwelling hose has excellent mechanical properties, anticoagulation properties and biocompatibility, and can effectively reduce the probability of blocking the hose and blood vessels and effectively reduce damage to human bodies, thereby effectively reducing suffering of patients.

Description

technical field [0001] The invention relates to a biomedical material in the field of medicine and medical equipment, in particular to an anticoagulant implant material, in particular to a polyvinyl alcohol-heparin polymer and its preparation method and application. Background technique [0002] Indwelling needles are commonly used in medicine and medical devices, and their core components include indwelling hoses and puncture needles for puncture guidance. When in use, the indwelling hose and the puncture needle are punctured into the blood vessel together, and when the indwelling hose has completely entered the blood vessel, the puncture needle is withdrawn, and only the indwelling hose is left in the blood vessel for infusion therapy. Therefore, the venous indwelling needle can reduce the pain of patients caused by repeated venipuncture, and at the same time reduce the workload of nurses, and is very popular among nurses and patients in clinic. [0003] Wherein, the indw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08F8/44C08F16/06C08L87/00
CPCC08F8/44C08G81/02C08L87/005C08F16/06
Inventor 陈绍永
Owner SIBIKANG XIAMEN NEW MATERIALS CO LTD
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