A metal-organic framework/electrospun fiber composite material with slow release synergistic effect of NO and copper ions and its preparation method and application

Abstract

The invention belongs to the field of biological materials, and in particular relates to a metal-organic framework / electrospinning fiber composite material with the synergistic effect of slow-release of NO and copper ions, and a preparation method and application thereof. The material consists of core-shell fibers interwoven into a patterned structure. The core-shell fibers use hydrophobic biomaterials as the core layer and hydrophilic biomaterials as the shell layer, and the core layer coats the NO-loaded copper-based MOF. The preparation includes: using a patterned receiving template, dispersing the NO-loaded copper-based MOF and dissolving the organic solvent of the hydrophobic biological material and connecting the inner needle of the coaxial electrostatic spray head, the organic solvent dissolving the hydrophilic biological material is connected to the inner needle of the coaxial electrostatic spray head. The outer needle was prepared by coaxial electrospinning. Aiming at the slow repair rate of diabetic wounds and insufficient angiogenesis, the slow release of NO and copper ions synergistically promote angiogenesis, collagen deposition and reduce inflammation in wound healing, greatly shortening the healing cycle of diabetic wounds .

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a metal-organic framework / electrospinning fiber composite material with the synergistic effect of slow-release of NO and copper ions, and a preparation method and application thereof. Background technique [0002] Diabetic trauma, as a wide range of chronic skin diseases, is characterized by the imbalance of blood glucose levels. Through complex pathophysiological mechanisms, various cell dysfunctions in the patient's wounds, and the expression of inflammatory factors and growth factors are unbalanced, resulting in angiogenesis in wound tissue. Difficulty, inflammatory hyperstimulation, difficult or even non-healing. [0003] As an important signaling molecule in the human body, nitric oxide (NO) plays a key role in the process of wound healing. NO can stimulate the expression of VEGF to promote the proliferation of endothelial cells and the formation of new blood vessels. It c...

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Problems solved by technology

[0005] Exogenous NO donors have become a research hotspot due to their advantages of controllable loading, controllable release rate, and directional release. However, traditional NO donors (organic nitrates, metal-NO complexes, nucleophilic-type Nitric oxide donors, etc.) have some common deficiencies, such as limited storage, limited release, poor stability, too fast release rate, short release cycle, difficulty in controlling the concentration, and donor toxicity, which often cannot meet the needs of wound treatment.

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