Rhizoma alismatis-largehead atractylodes rhizome tablet quality control method

A quality control method and technology of Zeshu tablets, applied in the field of medicine, can solve problems such as inability to meet quality control, and achieve the effects of ensuring safety and effectiveness, ensuring stability and good reproducibility
CN110441407AInactive Publication Date: 2019-11-12TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2019-11-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicine, and discloses a quality control method for detecting content of butenolide I, butenolide II and 23-acetyl alisol B in a rhizoma alismatis-largehead atractylodes rhizome tablet. The content of one or more components is determined simultaneously or separately by high performance liquid chromatography. C8 and C18 are used as fillers. Isocraticelution or gradient elution is carried out by using 0-100% acetonitrile or methanol as a mobile phase A and 100-0% ultrapure water or glacial acetic acid or a phosphoric acid solution as a mobile phase B. A flow rate is 0.1-2 ml / min, detection wavelength is 203-320 nm, and column temperature is 20-40 DEG C. The method of the invention controls the quality of active components of two medicinal materials in the prescription of the rhizoma alismatis-largehead atractylodes rhizome tablet, and so the quality control of the preparation is more comprehensive, accurate and effective, thereby helpingto ensure the medicine safety and validity. Moreover, the determination method has the advantages of simple operation, accurate result and good precision, stability and reproducibility, is an advancedquality control method and facilitates the standardized production of the medicine.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a quality control method of a traditional Chinese medicine compound. Specifically, the invention relates to a quality control method of Zezhu Tablets, especially one or more of Zezhu Tablet preparation prescriptions Alisma and Atractylodes Rhizoma. The content determination method of high performance liquid chromatography is carried out simultaneously or separately for two kinds of components. Background technique

[0002] Cardiovascular and cerebrovascular diseases are a serious threat to human beings, characterized by high prevalence, high disability and high mortality. The number of people who die from cardiovascular and cerebrovascular diseases is as high as 15 million every year in the world, ranking first among various causes of death. Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases, and hyperlipidemia is an important pathogenic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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