Medicine for restraining clostridium difficile thalli and/or restraining germination of clostridium difficile spores

Abstract

The invention provides an application of a compound as shown in the formula A to preparation of a medicine for restraining clostridium difficile thalli and / or restraining germination of clostridium difficile spores. R1 and R2 are independently selected from C1-3 alkyl group, C2-3 alkenyl and C2-3 alkynyl. Experiment proves that the compound as shown in the formula A, particularly magnolol and honokiol can notably restrain activity of clostridium difficile, can notably restrain germination of clostridium difficile spores, and has good application prospects for preparation of the medicine for preventing and / or treating clostridium difficile infection diseases, recurrence of clostridium difficile infection diseases, and complications of clostridium difficile infection diseases.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for inhibiting Clostridium difficile thallus and / or germination of Clostridium difficile spores. Background technique

[0002] Clostridium difficile (Clostridium difficile) is an obligate anaerobic bacterium of the genus Clostridium, which is very sensitive to oxygen and difficult to isolate and culture, hence the name, and generally parasitizes in the human intestinal tract. Usually Clostridium difficile infection is caused by excessive use of certain antibiotics, which breaks the balance of intestinal flora, makes the growth of Clostridium difficile flora accelerate, and causes inflammation. Clostridium difficile produces exotoxins A and B with different effects at different times. Toxin A is an enterotoxin, which first binds to mucosal cells in the early stage, causing primary damage, leading to inflammation of the intestinal wall, cell infiltration, i...

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