Dual drug loading system based on targeting pyrenin, preparing method and application

Abstract

The invention provides a dual drug loading system based on targeting pyrenin, a preparing method and application. The system is of a nanometer granular structure and comprises mesoporous silica nanometer particles, an anti-tumor drug and an AS1411 aptamer, wherein the anti-tumor drug is loaded in mesopores of the mesoporous silica nanometer particles, and the AS1411 aptamer is encapsulated on thesurfaces of the mesoporous silica nanometer particles. According to the dual drug loading system, the mesoporous silica nanometer particles are taken as a drug carrier, the AS1411 aptamer can target pyrenin which serves as a marker of tumor cells, and then through combined therapy of PMA and DOX, the MSN@PMA@DOX dual drug loading system for tumor targeting therapy is constructed. As is shown by experiment results, the dual drug loading system has an efficient targeting effect on the HeLa tumor cell pyrenin; meanwhile, the dual drug loading system has the advantages of accurate targeting, efficient therapy effect and the like.

Description

technical field [0001] The disclosure belongs to the technical field of biomedicine, and relates to a dual drug-loading system based on targeting nucleolin, a preparation method and an application. Background technique [0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art. [0003] Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. According to the cell characteristics of new organisms and the degree of harm to the body, tumors are divided into two categories: benign tumors and malignant tumors. Malignant tumors can be divided into carcinoma and sarcoma. Carcinoma refers to malignant tumors derived from epithelial tissue. Sarcomas refer to malignant tumors of mesenchymal tissues, including fibrous connective tissue, fat, muscle, blood vessels, bone and cartilage tissues. Antineoplastic drugs are a cl...

AI Technical Summary

Problems solved by technology

However, clinically used anti-tumor drugs usually have defects such as low selectivity, that is, while killing tumor cells, they can damage normal cells in the body, especially cells that proliferate vigorously.

These defects have become the main problems that limit the amount of anti-tumor drugs and hinder the efficacy of anti-tumor drugs.

Images