Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Responsive cross-linked polymer micelles based on multiple hydrogen bond interactions and their preparation methods and applications

A technology of cross-linked polymers and multiple hydrogen bonds, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, emulsion delivery, etc., can solve the problem of low targeting of cancer cells, premature release of drug delivery, and slow release speed And other issues

Active Publication Date: 2021-09-14
SHAANXI NORMAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the transport of polymer micelles in the body, there will be a phenomenon of sudden drug release, which leads to the problem of premature release of the drug and low targeting of cancer cells.
After the burst release, due to the diffusion of the drug, its release rate becomes very slow, and there is certain drug toxicity to normal cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Responsive cross-linked polymer micelles based on multiple hydrogen bond interactions and their preparation methods and applications
  • Responsive cross-linked polymer micelles based on multiple hydrogen bond interactions and their preparation methods and applications
  • Responsive cross-linked polymer micelles based on multiple hydrogen bond interactions and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]

[0042] 1. Dissolve CTA (7.2800g, 20mmol), dry mPEG (10.0000g, 5mmol) and DMAP (0.2440g, 2mmol) in 60mL CH 2 Cl 2 After being completely dissolved, EDC (1.9170g, 10mmol) was added, reacted at 25°C for three days, and the insoluble matter was removed. After concentration, the solution was precipitated twice in ether to obtain a light yellow solid. The resulting solid was dissolved in 80 mL CH 2 Cl 2 In, with saturated Na 2 CO 3 The aqueous solution was washed three times, and the obtained organic phase was dried over anhydrous sodium sulfate for 12 hours. Filtration, after most of the solvent is removed by rotary evaporation, precipitation in excess glacial ether, to obtain light yellow powder solid, namely the macromolecular chain transfer agent (mPEG) shown in formula I-1 39 -CTA).

[0043] 2. The mPEG 39 -CTA (0.7002g, 0.3mmol), DMAEMA (1.5700g, 10mmol), UPy-HEMA (0.4367g, 1.1mmol) and AIBN (0.0164g, 0.1mmol) were added to a 50mL Shrek tube, and 5mL DMSO wa...

Embodiment 2

[0047]

[0048] 1. Dissolve CTA (6.552g, 18mmol), dry mPEG (4.0000g, 2mmol) and DMAP (0.2440g, 2mmol) in 60mL CH 2 Cl 2 After being completely dissolved, EDC (1.5336g, 8mmol) was added, and the insoluble matter was removed after three days of reaction at 25°C. The solution was concentrated and precipitated twice in ether to obtain a light yellow solid. The resulting solid was dissolved in 80 mL CH 2 Cl 2 In, with saturated Na 2 CO 3 The aqueous solution was washed three times, and the obtained organic phase was dried over anhydrous sodium sulfate for 12 hours. Filtrate, after rotary evaporation removes most of solvent, precipitate in excess glacial ether, obtain pale yellow powder solid, the macromolecular chain transfer agent (mPEG) shown in formula I-2 32 -CTA).

[0049] 2. The mPEG 32 -CTA (0.4668g, 0.2mmol), DMAEMA (1.4444g, 9.2mmol), UPy-HEMA (0.3176g, 0.8mmol) and AIBN (0.0164g, 0.1mmol) were added to a 50mL Shrek tube, and 5mL DMSO was added to make It was di...

Embodiment 3

[0053]

[0054] 1. Dissolve CTA (8.008g, 22mmol), dry mPEG (6.0000g, 3mmol) and DMAP (0.2440g, 2mmol) in 60mL CH 2 Cl 2 After being completely dissolved, EDC (2.3004g, 12mmol) was added, reacted at 25°C for three days, and the insoluble matter was removed. After concentration, the solution was precipitated twice in ether to obtain a light yellow solid. The resulting solid was dissolved in 80 mL CH 2 Cl 2 In, with saturated Na 2 CO 3 The aqueous solution was washed three times, and the obtained organic phase was dried with anhydrous sodium sulfate for 12 hours. Filtration, after rotary evaporation removes most of solvent, precipitate in excess glacial ether, obtain light yellow powder solid, the macromolecular chain transfer agent (mPEG) shown in formula I-3 35 -CTA).

[0055] 2. The mPEG 35 -CTA (0.2334g, 0.1mmol), DMAEMA (1.4915g, 9.5mmol), UPy-HEMA (0.1985g, 0.5mmol) and AIBN (0.0164g, 0.1mmol) were added to a 50mL Shrek tube, and 5mL DMSO was added to make It was...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a responsive cross-linked polymer micelle based on multiple hydrogen bond interactions and its preparation method and application. 1 80~110 integers, y 2 It is an integer of 3 to 15; it is an amphiphile with dimethylaminoethyl methacrylate as the hydrophilic chain and ureidopyrimidinone groups with multiple hydrogen bond interactions as the hydrophobic chain by a simple "one-pot method". It is a block copolymer, which self-assembles in water to form uniform and stable core cross-linked micelles, and then reacts with N,N'-bis(bromoacetyl)cystamine to prepare it. The responsive cross-linked polymer micelle based on multiple hydrogen bond interactions of the present invention is used as a drug delivery carrier to entrap Nile Red. The results show that it has good stability and reasonable controlled release ability, and has great potential in drug delivery. , has great application prospects.

Description

technical field [0001] The invention belongs to the technical field of stimuli-responsive polymer materials, and in particular relates to a responsive cross-linked polymer micelle based on multiple hydrogen bond interactions, as well as a preparation method and application of the polymer micelle. Background technique [0002] Life forms in nature have undergone hundreds of millions of years of evolution, and have almost perfected all processes of intelligent control. Learning from nature is a source of inspiration for humans to develop new materials for artificial intelligence. DNA in organisms uses double hydrogen bonds and triple hydrogen bonds to self-replicate and store information, and uses this relatively strong but reversible effect to ensure the accuracy of genetic information replication. In recent years, many researchers at home and abroad have devoted themselves to exploring and studying multiple hydrogen bond units to construct supramolecular assemblies, and sti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F220/34C08F220/36C08J3/24C08J3/02A61K9/107A61K47/32
CPCA61K9/1075A61K47/34C08F220/34C08F220/36C08F293/005C08F2438/03C08J3/02C08J3/24
Inventor 雷忠利周琪杨红
Owner SHAANXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com