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Preparation method of soluble cellulose nasal dressing

A cellulose and completely dissolving technology, which is applied in the direction of pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of inability to support and fix nasal bone tissue, low mechanical strength of packing materials, and residual harmful substances, etc., and achieve good product conversion feasibility, The effect of good biosecurity and reducing safety risks

Active Publication Date: 2019-11-26
浙江美华鼎昌医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commercially available packing materials mainly have the following problems: 1. The polymer is prepared by chemical cross-linking by adding a chemical cross-linking agent, the preparation process is complicated, there are some uncontrollable factors, and certain harmful substances will remain; 2. The packing material The mechanical strength of the degradable packing material is small, and it cannot support and fix the nasal bone tissue; 3. After the operation, the packing material needs to be removed through a second operation, which will increase the pain of the patient again; 4. The degraded products of the degradable packing material may be absorbed by the human body, and there is a certain degree of safety. risk

Method used

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  • Preparation method of soluble cellulose nasal dressing
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  • Preparation method of soluble cellulose nasal dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of dissolvable cellulose nasal dressing, comprising the following steps:

[0028] (1) Prepare an aqueous solution of hydrochloric acid with a certain mass concentration so that its pH is 4, slowly add a certain amount of CMC-Na powder to it, adjust the temperature to 25°C, stir at a speed of 100r / min to completely dissolve it, and form a 3wt % CMC-Na solution;

[0029] (2) Fill the CMC-Na solution gained in step (1) in a mould, put it into a freeze-drying box, set the initial temperature to 0°C, then gradually cool to -45°C to freeze, and then freeze the freeze-drying box Vacuum, and then raise the temperature to 40°C for drying to obtain a spongy solid;

[0030] (3) softening the spongy solid obtained in step (2) by freeze-drying at a temperature of 50° C. and a humidity of 50% for 48 hours;

[0031] (4) The nasal dressing softened in step (3) is sealed and packaged, and subjected to E-beam electron beam sterilization with a sterilization dose ra...

Embodiment 2

[0036] A preparation method of dissolvable cellulose nasal dressing, comprising the following steps:

[0037] (1) Prepare an aqueous solution of hydrochloric acid with a certain mass concentration so that its pH is 4, slowly add a certain amount of CMC-Na powder to it, adjust the temperature to 25°C, stir at a speed of 100r / min to completely dissolve it, and form 5wt % CMC-Na solution;

[0038] (2) Fill the CMC-Na solution gained in step (1) in a mould, put it into a freeze-drying box, set the initial temperature to 0°C, then gradually cool to -45°C to freeze, and then freeze the freeze-drying box Vacuum, and then raise the temperature to 40°C for drying to obtain a spongy solid;

[0039] (3) softening the spongy solid obtained in step (2) by freeze-drying at a temperature of 50° C. and a humidity of 50% for 48 hours;

[0040] (4) The nasal dressing softened in step (3) is sealed and packaged, and subjected to E-beam electron beam sterilization with a sterilization dose rang...

Embodiment 3

[0045] A preparation method of dissolvable cellulose nasal dressing, comprising the following steps:

[0046] (1) Prepare an aqueous solution of hydrochloric acid with a certain mass concentration so that its pH is 1, slowly add a certain amount of CMC-Na powder to it, adjust the temperature to 40°C, stir at a speed of 300r / min to completely dissolve it, and form a 3wt % CMC-Na solution;

[0047](2) Fill the CMC-Na solution gained in step (1) in a mould, put it into a freeze-drying box, set the initial temperature to 0°C, then gradually cool to -45°C to freeze, and then freeze the freeze-drying box Vacuum, and then raise the temperature to 40°C for drying to obtain a spongy solid;

[0048] (3) softening the spongy solid obtained in step (2) by freeze-drying at a temperature of 80° C. and a humidity of 90% for 15 hours;

[0049] (4) The nasal dressing softened in step (3) is sealed and packaged, and sterilized by gamma rays with a sterilization dose ranging from 25 to 35 KGy ...

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Abstract

The present invention discloses a preparation method for a soluble cellulose nasal dressing. Sodium carboxymethyl cellulose (CMC-Na), a derivative of natural cellulose, is dissolved in an acidic medium, and freeze-drying, softening, sub-packaging, sterilizing and other processes are conducted to prepare the soluble cellulose nasal dressing. The soluble cellulose nasal dressing is mainly used for postoperative patient nasal stuffing, can quickly absorb blood swelling, compresses bleeding points to reduce amount of bleeding, supports nasal bone tissues, and can also effectively prevent adhesionsin nasal mucosa. A slight dissolution is observed 2 days after the nasal dressing is stuffed into a nasal cavity. After 7 days, the nasal dressing is basically completely dissolved, can naturally flow out without having a second surgery to remove out, and greatly reduces patients' pains.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a dissolvable cellulose nasal dressing. Background technique [0002] With the rapid development and wide application of nasal functional endoscopic surgery, the material and performance of nasal packing have also attracted much attention. The main purpose of nasal packing is to keep the nasal cavity open, absorb fluid and blood, and prevent surgery. Adhesions of the posterior nasal lining. [0003] At present, the commercially available packing materials mainly have the following problems: 1. The polymer is prepared by chemical cross-linking by adding a chemical cross-linking agent, the preparation process is complicated, there are some uncontrollable factors, and certain harmful substances will remain; 2. The packing material The mechanical strength of the degradable packing material is small, and it cannot support and fix the nasal bone ti...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/50A61L15/64
CPCA61L15/28A61L15/42A61L15/425A61L15/44A61L15/50A61L15/64A61L2400/04C08L1/286
Inventor 杜静戴春燕黄存东王传跃
Owner 浙江美华鼎昌医药科技有限公司
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