Special matrix for plaster and patch

Abstract

The invention discloses a special matrix for a plaster and a patch. The special matrix comprises the following raw materials in percentage by mass: 28% of a skeleton-type adhesive, 5% of a water-soluble adhesive, 4% of a tackifier, 4% of a filler, 18% of a plasticizer, 5% of an anti-aging agent, 10% of a cosolvent, 2% of a cross-linking agent, 4% of a PH regulator, 4% of bacteriostat, 12% of a humectant and 4% of a transdermal absorption enhancer. The matrix has the advantages of safe and reliable components, no toxic or side effect, convenient use, no need of heating, direct cold compress, strong adhesive force, sweat resistance, water resistance, no allergy, difficult removal, and no residual and no pollution on the skin after removal. The efficient application time of can reach more than 72 hours when one patch is applied. The matrix contains muscone component, and the prepared plaster has high effective component permeability, high biocompatibility, good transdermal absorption andobvious curative effect. The process is mature, the quality is stable, the cost is reasonable, and the industrial application is facilitated.

Description

technical field [0001] The invention relates to a special matrix for plasters and patches, in particular to a special matrix for plasters and patches and a preparation method thereof. Background technique [0002] Plaster matrix is ​​the main component of plaster making, and is the important material and technical basis of plaster preparations, which determines the preparation, quality and curative effect of plaster products. According to inquiries, there are roughly the following categories of plaster patent bases at present, each of which has its own strengths and weaknesses in technology, which are now described as follows: [0003] The first category is the traditional plaster base. The production has a long history and is mostly manual operation. The preparation of production is based on experience and family traditions. Affected by seasonality, the initial adhesion in winter is insufficient and external heating is required before application. In spring and autumn, the...

AI Technical Summary

Problems solved by technology

It is made by mixing and heating hot melt adhesive and solvent type. It has the advantages of good viscosity, but less drug content, poor permeability and short action time.

[0006] The fourth type is the hot-melt pressure-sensitive adhesive plaster base containing natural rubber. The stickiness is too strong, it is easy to stick to hair, and there is pain when it is torn off. It is easy to fall off in case of slight moisture or dander, so it cannot be applied repeatedly

[0009] 2) Poor permeability, which affects the transdermal absorption of drugs and low bioavailability;

[0010] 3) The adhesive force of the matrix is ​​difficult to control, resulting in poor anti-perspiration, waterproof, and adhesive properties of plaster products;

[0011] 4) It is greatly affected by the seasonal temperature, and the application is easy to slip in summer;

[0012] 5) The shelf life of the matrix is ​​short, usually about one year;

[0013] 6) Easy to contaminate skin and clothing;

[0014] 7) The production cost is high, the energy waste is large, and the production pollution and safety hazards are relatively large;

[0015] 8) It is easily affected by low temperature, and the storage and production of matrix raw materials are difficult;

[0016] 9) The matrix uses natural rubber, its cohesion is too large, it is easy to pollute and damage the skin and fur