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Preparation method of hectorite reinforced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomplex hydrogel

A technology of polyethylene glycol and stereocomposition, which is applied in the preparation of biomedical materials and the field of polymer composite materials

Inactive Publication Date: 2019-12-17
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is: provide a kind of preparation method of polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano-stereo-composite hydrogel that hectorite strengthens, to solve the polylactic acid in the prior art Limitations of low physical and mechanical properties of lactic acid-polyethylene glycol-polylactic acid triblock hydrogels

Method used

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  • Preparation method of hectorite reinforced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomplex hydrogel
  • Preparation method of hectorite reinforced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomplex hydrogel
  • Preparation method of hectorite reinforced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomplex hydrogel

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preparation example Construction

[0017] The preparation method of polylactic acid-polyethylene glycol-polylactic acid is:

[0018] The PLLA-PEG-PLLA triblock copolymer was synthesized by PEG macromolecule-initiated lactide ring-opening polymerization, and the synthetic reaction scheme is shown below.

[0019]

[0020] Wherein, x=2000, y=800.

[0021] In the first step, a certain proportion of left-handed (L) (or right-handed D)-lactide, polyethylene glycol (PEG), stannous octoate is added in a 100mL three-necked round-bottomed flask, and N 2 After a few minutes, add a certain amount of toluene solution, stir evenly with magnetic force, and react at 120°C for 8 hours;

[0022] In the second step, the product obtained by the reaction was taken out, cooled to room temperature, and precipitated with glacial ether to obtain a white solid product;

[0023] In the third step, the white solid was dissolved with dichloromethane, stirred, dropped into glacial ether for precipitation, and suction filtered. This pro...

Embodiment 1

[0028] Preparation steps of hectorite-enhanced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer stereocomposite hydrogel:

[0029] In the first step, 2g of PLLA-PEG-PLLA or PDLA-PEG-PDLA was dissolved in 4ml of tetrahydrofuran, and then added dropwise into a 15ml sample bottle filled with 8ml of deionized water. Stir evenly with a magnetic stirrer and let stand overnight at 4° C., then reduce the pressure to evaporate and remove THF in the blend to obtain a micellar solution with a concentration of 20%.

[0030] In the second step, under the condition of 4°C, first blend 20% PLLA-PEG-PLLA and PDLA-PEG-PDLA micellar solutions according to 1:1 to obtain a stereomicelle solution, and then the stereomicelle The solution and the ultrapure aqueous solution are vibrated and mixed at a ratio of 1:1 to obtain a polylactic acid-polyethylene glycol-polylactic acid triblock copolymer stereocomposite hydrogel, and then heated to obtain a structurally stable composite ...

Embodiment 2

[0032] The preparation steps of the polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomposite hydrogel reinforced by hectorite:

[0033] In the first step, 2g of PLLA-PEG-PLLA or PDLA-PEG-PDLA was dissolved in 4ml of tetrahydrofuran, and then added dropwise into a 15ml sample bottle filled with 8ml of deionized water. Stir evenly with a magnetic stirrer and let stand overnight at 4° C., then reduce the pressure to evaporate and remove THF in the blend to obtain a micellar solution with a concentration of 20%.

[0034] The second step is to weigh a certain amount of laponite powder and sodium pyrophosphate, the ratio of hectorite to sodium pyrophosphate is 10:1, and then add sodium pyrophosphate to a beaker with a certain amount of ultrapure water Then add hectorite powder slowly to the sodium pyrophosphate solution stirred with a magnetic stirrer, seal it with a plastic wrap to avoid water evaporation, and then stir overnight to obtain a conce...

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Abstract

The invention discloses a hectorite reinforced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano stereocomplex hydrogel. The polylactic acid-polyethylene glycol-polylactic acid triblock copolymer hydrogel is enhanced through the enhancement effect of nano hectorite and the stereocomplex effect of a polylactic acid chain segment, and the physical and mechanical propertiesof the composite hydrogel are obviously improved.

Description

technical field [0001] The invention relates to a method for preparing hectorite-enhanced polylactic acid-polyethylene glycol-polylactic acid triblock copolymer nano-stereocomposite hydrogel, which belongs to the field of preparation of polymer composite materials and biomedical materials. Background technique [0002] Hydrogel is a class of materials with high water content and three-dimensional network structure, which has a wide range of applications in the fields of smart materials and biomedicine. Polylactic acid-polyethylene glycol-polylactic acid triblock copolymer is a polymer copolymer with good biocompatibility and degradability. It has both hydrophilic and hydrophobic properties. It is used in the field of biomedicine It has broad application prospects. Structurally, since the polylactic acid segment in the polylactic acid-polyethylene glycol-polylactic acid triblock copolymer has two isomers, left-handed and right-handed, the copolymers of the two isomers can be...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L67/00C08K3/34C08K3/32
CPCC08J3/075C08J2367/00C08J2467/00C08K3/34C08K2003/321
Inventor 何敏龚勇吉刘玉飞于杰秦舒浩
Owner GUIZHOU UNIV
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