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A kind of preparation method of silk fibroin scaffold material capable of sustained release of long-acting drugs

A technology of silk fibroin and scaffold materials, which is applied in the field of preparation of silk fibroin scaffold materials, can solve the problems of poor drug slow-release effect and complicated preparation process, and achieve a simple and controllable preparation process suitable for large-scale industrial promotion. The effect of high drug loading rate

Active Publication Date: 2022-02-08
PEKING UNIV THIRD HOSPITAL
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Problems solved by technology

[0008] The purpose of the present invention is to provide a preparation method of a silk fibroin scaffold material capable of sustained release of long-acting drugs, so as to solve the problems in the prior art that the drug slow release effect mainly based on silk fibroin is not good, and the preparation process is complicated.

Method used

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  • A kind of preparation method of silk fibroin scaffold material capable of sustained release of long-acting drugs
  • A kind of preparation method of silk fibroin scaffold material capable of sustained release of long-acting drugs
  • A kind of preparation method of silk fibroin scaffold material capable of sustained release of long-acting drugs

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preparation example Construction

[0033] The application provides a preparation method of a silk fibroin scaffold material capable of sustained release of long-acting drugs, comprising the following steps:

[0034] 1) Silk fibroin extraction

[0035] 10g silkworm cocoons are cut into small pieces with scissors, and put into after boiling 0.02mol / L anhydrous sodium carbonate solution (2L), keep stirring and dissolving under boiling state for 30min, take out the white cotton-like solid obtained, wash with water several times, and dry at room temperature. After fully drying, weigh and take the corresponding lithium bromide with the mass ratio of silk fibroin: lithium bromide = 1:4. Equipped with a 9.3mol / L lithium bromide aqueous solution (calculate the liquid volume first, then weigh about 60% of the water, put it in an ice bath, and at the same time slowly add lithium bromide to the stirring water, make up the volume to the calculated value after completely dissolving), and mix the solution Pour into a beaker...

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Abstract

The invention relates to a preparation method of a silk fibroin scaffold material capable of sustained release of long-acting drugs. The silk fibroin frozen sponge prepared by liquid nitrogen quick-freezing is used as a carrier of slow-release drugs, and the low-temperature self-assembly characteristics of silk fibroin are used to realize Drug encapsulation and sustained release, and according to the technical route from silk fibroin solution preparation to final drug loading, that is, differential thermal experiments to find the glass transition temperature-drug addition-low temperature cryopreservation-thawing and use, to achieve long-term controllable drug Sustained release. Compared with other drug-loaded forms, the implementation of this technology has no toxic additives, does not require chemical cross-linking agents and organic solvents, and has a very high drug-loading rate, and the preparation process of this technical solution is simple and controllable, suitable for large-scale industrial promotion .

Description

technical field [0001] The invention belongs to the technical field of tissue damage repair, in particular to a preparation method of a silk fibroin scaffold material capable of sustained release of long-acting drugs. Background technique [0002] Drug therapy with various small molecule drugs and cytokines as the core is one of the key areas in the current clinical drug research and development. In addition to the need to regulate the activity and efficacy of drugs, how to screen and construct suitable drug controlled release carriers also plays an important role in drug development. For different lesions and diseases, drug carriers need to find a balance between burst release and sustained release. In addition to the need to use drugs for disease treatment, sustained and burst release of drugs is also of great significance in the field of tissue engineering. [0003] When constructing tissue engineering scaffolds, on the one hand, drugs need to be used to quickly recruit...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/54A61L27/22
CPCA61L27/58A61L27/54A61L27/227A61L2300/604
Inventor 敖英芳孙牧旸胡晓青
Owner PEKING UNIV THIRD HOSPITAL
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