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Gradient porous magnesium-based metal component body for bone tissue engineering and preparation method thereof

A technology of bone tissue engineering and gradient porosity, which is applied in tissue regeneration, prosthesis, medical science, etc., can solve problems such as high dependence on pressure equipment, residual pore-forming agents, and single porous magnesium structure, so as to avoid adverse effects and quickly Degradation rate, effect of reducing dependence

Active Publication Date: 2022-03-22
CHINA WEAPON SCI ACADEMY NINGBO BRANCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with the above method is that the prepared porous magnesium has a single structure, and it is difficult to prepare a gradient porous magnesium metal scaffold structure, which cannot meet the performance requirements of the porous magnesium scaffold material in different implantation periods, seriously affecting the bone repair effect
Among them, the load and loading method of the external pressure need to be accurately controlled, so the dependence on the pressure equipment is high; and when the gradient porous magnesium is prepared by adjusting the mixing ratio between the metal powder and the pore-forming agent, it is easy to cause the sintered product to be sintered. Pore ​​agent remains, which can adversely affect cell growth around the implant

Method used

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  • Gradient porous magnesium-based metal component body for bone tissue engineering and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0028] Such as figure 1As shown, the bone tissue engineering gradient porous magnesium-based metal component body of the embodiment of the present invention includes an inner core preform 1, an intermediate preform 2 and an outer layer preform 3, wherein the intermediate preform 2 is located at the periphery of the inner core preform 1, and It is ring-shaped; the outer layer prefabricated body 3 is located on the periphery of the middle layer prefabricated body 2 and is ring-shaped; the above-mentioned inner layer prefabricated body 1, middle layer prefabricated body and outer layer prefabricated body 3 all have pores, and the inner layer prefabricated body 1, the middle layer prefabricated body 1, the middle layer prefabricated body The body 2 and the outer layer preform 3 are connected through their respective pores. The porosity refers to the ratio of the pores inside the material to the total volume in the apparent volume of the granular material. In this embodiment, the in...

Embodiment 2

[0037] The difference between this embodiment and the above-mentioned embodiment 1 is only that: the matrix material of the ball-milled magnesium powder or the gas-atomized magnesium powder is different, and the constant external pressure adopted is different.

[0038] The preparation method of the above-mentioned gradient porous magnesium-based metal component for bone tissue engineering in this embodiment includes the following steps in sequence:

[0039] First, the extruded Mg-Sr binary alloy is selected as the base material to prepare gas-atomized magnesium powder 4 and ball-milled magnesium powder 5; wherein the alloy is used as the base material for gas-atomization to obtain gas-atomized magnesium powder. Magnesium alloy powder, the ball-milled magnesium powder obtained after ball-milling the alloy as the base material is ball-milled magnesium alloy powder; secondly, an electric cold isostatic press is used to adjust the constant external pressure to 50MPa, and the ball-m...

Embodiment 3

[0042] The difference between this embodiment and the above-mentioned embodiment 1 is only that: the matrix material of the ball-milled magnesium powder or the gas-atomized magnesium powder is different, and the constant external pressure adopted is different.

[0043] The preparation method of the above-mentioned gradient porous magnesium-based metal component for bone tissue engineering in this embodiment includes the following steps in sequence:

[0044] First, the extruded Mg-RE-Zr ternary alloy is selected as the base material to prepare gas atomized magnesium powder 4 and ball milled magnesium powder 5; wherein the alloy is used as the base material for gas atomization to obtain gas atomized magnesium powder as the gas Atomized magnesium alloy powder, the ball milled magnesium powder obtained after ball milling the alloy as the base material is ball milled magnesium alloy powder; secondly, an electric cold isostatic press is used to adjust the constant external pressure t...

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Abstract

The invention relates to a gradient porous magnesium-based metal component body for bone tissue engineering, which is characterized in that it at least includes an inner core prefabricated body, a ring-shaped outer layer prefabricated body located on the periphery of the inner core prefabricated body, and an inner inner prefabricated body and an outer layer prefabricated body. Between the ring-shaped middle layer prefabricated body, the core prefabricated body, the middle layer prefabricated body and the outer layer prefabricated body all have pores, and the pores of the three are connected, and the inner core prefabricated body, the middle layer prefabricated body The porosity of the body and the outer prefabricated body decreases sequentially. The invention also relates to a preparation method. After being implanted in the human body, it can meet the different requirements for dynamic matching between degradation rate and mechanical properties in different periods.

Description

technical field [0001] The invention relates to the technical field of orthopedic internal implant medical devices, in particular to a gradient porous magnesium-based metal component body for bone tissue engineering and a preparation method thereof. Background technique [0002] Bone defect is one of the common clinical diseases in orthopedic medicine. Small-sized bone defects can heal on their own, while larger-sized bone defects are usually difficult to heal automatically and need to be treated by bone grafting or implantation of substitutes. [0003] The existing bone defect treatment method is to use scaffold materials made of magnesium-based metal materials. The scaffold materials are the basic components of tissue-engineered bones. Magnesium-based metal materials have the characteristics of good biocompatibility and degradable absorption in the human body. It is a new type of biodegradable (absorbing) metal material with great clinical application prospects. Due to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/58A61L27/04B22F3/04B22F3/11B22F7/02
CPCA61L27/56A61L27/58A61L27/047B22F3/04B22F3/11B22F7/002A61L2430/02B22F2998/10
Inventor 刘辰柏关顺徐永东朱秀荣任政庞松王军邵志文
Owner CHINA WEAPON SCI ACADEMY NINGBO BRANCH
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