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Application of polyethylene glycol activated ester in the preparation of low-swelling hydrogel and low-swelling hydrogel including the same

A technology of polyethylene glycol and polyethylene glycol succinimide sebacate, applied in application, surgery, tissue regeneration, etc., can solve the problems of inapplicability, easy to cause human injury, etc., and achieve good low swelling effect of effect

Active Publication Date: 2022-05-17
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The second object of the present invention is to provide a low-swelling hydrogel, said low-swelling hydrogel includes the above-mentioned polyethylene glycol activated ester, the hydrogel effectively relieves the generally high swelling rate of existing hydrogels , can not be applied to nerves in a limited space, and it is often easy to cause human injury

Method used

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  • Application of polyethylene glycol activated ester in the preparation of low-swelling hydrogel and low-swelling hydrogel including the same
  • Application of polyethylene glycol activated ester in the preparation of low-swelling hydrogel and low-swelling hydrogel including the same
  • Application of polyethylene glycol activated ester in the preparation of low-swelling hydrogel and low-swelling hydrogel including the same

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preparation example Construction

[0126] According to one aspect of the present invention, a kind of preparation method of above-mentioned low-swelling hydrogel, described preparation method comprises the following steps:

[0127] The components are mixed and then extruded to obtain a hydrogel.

[0128] The invention provides a method for preparing a low-swelling hydrogel. In the preparation method, various components are mixed and then extruded to obtain a hydrogel. The above method has the advantages of simple steps, simple operation and easy industrialized large-scale production.

[0129] In a preferred embodiment of the present invention, the preparation method comprises the following steps:

[0130] (I), the polyethylene glycol activated ester is dissolved in the buffer to obtain solution A;

[0131] (II), dissolving the cross-linking agent in buffer or pure water and mixing to obtain solution B;

[0132] (Ⅲ), then extrude after mixing solution A, solution B, optional dyeing agent, optional drug and op...

Embodiment 1～7

[0141] A kind of hydrogel, the selection of polyethylene glycol activated ester in described embodiment 1~4 hydrogel is shown in the table below:

[0142]

[0143] The selection of polyethylene glycol activated esters in the hydrogels of Examples 5 to 7 is shown in the table below:

[0144] group Polyethylene glycol activated ester types Proportion Example 5 PEG3350-SG:PEG3350-SA 0.5:1.5 Example 6 PEG3350-SG:PEG3350-SSeb 1:1 Example 7 PEG3350-SG:PEG3350-SSeb 0.5:1.5

[0145] The hydrogels of Examples 1-7 consist of the following components:

[0146] (a) 0.5 g of polyethylene glycol activated esters;

[0147] (b) Trilysine (15g / L)-borate buffer (65mM) 2.5mL, pH=9.8;

[0148] (c) 0.1 mL of polyethyleneimine (molecular weight 1800) mass fraction 10% aqueous solution;

[0149] (d) Phosphate buffer (1.5mM) 2.4mL, pH=4.0;

[0150] The preparation method of described embodiment 1~7 hydrogel comprises the following steps:

[0151] Diss...

experiment example 1

[0153] In order to show that the hydrogels prepared in the present application have a lower swelling rate, the inventors tested the swelling rates of the hydrogels prepared in Examples 1 to 7 above, and the specific detection methods are as follows:

[0154] The hydrogel prepared above was weighed and transferred to a ground-mouth Erlenmeyer flask, and added to a pH 7.4 phosphate buffer preheated to 37±1° C. g, add 79mL of 0.1mol / mL sodium hydroxide solution, dilute to 200mL with water to obtain a phosphate buffer solution with a pH of 7.4), put the ground-mouthed Erlenmeyer flask into an incubator at 37±1°C, and take it out every few hours Use filter paper to absorb the surface moisture of the sample, weigh it, and stop weighing until the weight no longer increases. Calculate the gel swelling rate according to the following formula.

[0155] Swelling rate = (sample mass after swelling - sampling amount) × 100% / sample amount.

[0156] It is detected by the above method that:...

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Abstract

The invention provides the application of polyethylene glycol activated ester in preparing low-swelling hydrogel and the low-swelling hydrogel including the same, and relates to the technical field of new medical materials. The above-mentioned low-swelling hydrogel is a hydrogel with a swelling rate of <50%, and the hydrogel is obtained by using a longer degradable carbon chain (the value of m in the structural formula is a positive integer of 3 to 10) and polyethylene glycols The hydrogel with a molecular weight of 3,000-10,000 Daltons in the polyethylene glycol part of the activated ester has a very good low-swelling effect, which effectively alleviates the general high swelling rate of existing hydrogels and cannot be applied to nerves in limited spaces. It is often easy to cause bodily harm. The above-mentioned low-swelling hydrogel can be widely used in the preparation process of biomedical material products, especially in the preparation of tissue sealant for skull and / or spine.

Description

technical field [0001] The invention relates to the technical field of new medical materials, in particular to the application of a polyethylene glycol activated ester in the preparation of low-swelling hydrogel and the low-swelling hydrogel comprising the same. Background technique [0002] As a biocompatible material, hydrogel is mainly used in medicine for anti-adhesion after surgery, hemostatic agent, filling of defective tissue, preventing interstitial fluid leakage, and slow release of drugs. The swelling rate of the existing biodegradable material hydrogel is relatively high, and the swelling rate is generally 50-600%. When these hydrogels are used as human tissue sealants, due to the generally high swelling rate, they cannot be applied to nerves in limited spaces, and often cause adverse events of human injury. For example, the swelling rate of spinal sealants is too high. Compression can cause pain to the patient, and in severe cases can lead to numbness or even lo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L71/02C08L79/02C08K5/20A61L24/04A61L24/00
CPCC08J3/075A61L24/046A61L24/0031C08J2371/02C08J2477/04C08J2471/02C08K5/20A61L2430/02A61L2430/38
Inventor 苑康见董芳芳李刚贾德泽赵艳赵成如邓凤娟李正强
Owner SAIKE SAISI BIOTECH CO LTD