A strain of Proteus mirabilis phage rdp-sa-16033 and its industrial production process

A technology of RDP-SA-16033, Proteus mirabilis, applied in the field of microorganisms, can solve the problems of antibiotic abuse and bacterial resistance, and achieve the effects of high titer, good product stability, and high temperature tolerance
CN110684742BActive Publication Date: 2020-05-22RECOM QINGDAO BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
RECOM QINGDAO BIOTECH CO LTD
Publication Date
2020-05-22

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Abstract

The present invention discloses a Proteus mirabilis phage RDP-SA-16033. The host of the Proteus mirabilis phage is Proteus mirabilis S5. The phage may form a plaque having a diameter of 4-6 mm on a double-layer plate. When observed through an electron microscope, the phage has a head in polyhedral cubic symmetry, is coated by nucleic acid, has a diameter of about 70 nm, has a tail of about 150 nm long, has a tail sheath, has a neck connected to the head and the tail, and belongs to tailed virales myovirus division. The present invention further provides a production process of the phage. After centrifugation of value-added liquid, a titer of the phage is increased by membrane concentration, and then residual host and other infectious microbes in value-added are effectively removed by a ceramic membrane and a 0.22 μm polyethersulfone filter membrane. Meanwhile, the phage is reserved to the utmost extent.
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Description

technical field

[0001] The invention relates to the field of microorganisms, in particular to a Proteus mirabilis phage RDP-SA-16033 and its industrial production process. Background technique

[0002] Proteus mirabilis is a Gram-negative bacterium with no spores, no capsule, flagella all over the body, and obvious pleomorphism. Its growth and reproduction do not require high nutrition, and it can reproduce at 4-7°C. The bacterium widely exists in human and animal feces, sewage, soil and clinical specimens, and the toxin it produces can cause poisoning, so it is a common opportunistic pathogen. Proteus mirabilis not only infects common domestic animals such as chickens, pigeons, goats, cows and pigs, but also animals such as monkeys, foxes, pandas and minks. It can cause surgical infections, urinary system infections, diarrhea and bacterial blood disease etc. In recent years, Proteus mirabilis disease outbreaks have continued to occur in chicken flocks in Henan, Hebei, Sha...

Claims

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