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Duck natural immunity reinforcing agent based on pattern recognition receptor ligand

A technology of pattern recognition receptors and natural immunity, applied in the field of agriculture, can solve problems such as the detailed mechanism is not very clear, and achieve the effect of enhancing natural immune response and disease resistance of ducks

Active Publication Date: 2020-01-14
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on animal PRRs immunomodulators started relatively late. Although some studies have shown that some livestock and poultry PRRs ligands have potential immune regulation effects, which can induce DC activation to produce a large amount of IL-12 and type I interferon, which are important in the body's natural immune response. It plays a very important role, but the detailed mechanism of its action is not very clear, and the application in livestock and poultry production is still rarely reported

Method used

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  • Duck natural immunity reinforcing agent based on pattern recognition receptor ligand
  • Duck natural immunity reinforcing agent based on pattern recognition receptor ligand
  • Duck natural immunity reinforcing agent based on pattern recognition receptor ligand

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Experimental program
Comparison scheme
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Embodiment Construction

[0016] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments.

[0017] 1. Synthesis of duck natural immune enhancer

[0018] According to the ligand molecular structure of animal PRRs family member TLR9, design and synthesize duck natural immune enhancer.

[0019] 2. Experimental animal grouping and treatment

[0020] The 1-day-old ducklings hatched from the same batch were selected, and after 7 days of adaptive feeding, they were randomly divided into a test group and a control group, with 20 ducklings in each group. The ducklings in the test group were subcutaneously injected with a synthetic duck natural immune enhancer (5 μg / feather), and the ducklings in the control group were subcutaneously injected with the same volume of normal saline for 3 consecutive days. During the experiment, ducklings in each group had free access to food and water.

[0021] 3. Sample collection

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Abstract

The invention discloses a duck natural immunity reinforcing agent based on a pattern recognition receptor ligand. The sequence of the duck natural immunity reinforcing agent based on a pattern recognition receptor ligand is 5'-GATATGCGACCGATT-3'. The duck natural immunity reinforcing agent based on a pattern recognition receptor ligand provided by the invention can significantly raise the level ofduck serum cytokines IL-1 beta / 12p40, IL-1 beta, IFN-alpha and IFN-beta, raise the tissue expression level of natural immunity related genes RIG-I, TLR3, TLR7, IFN-alpha, IFN-brta, IL-1 beta and TNF-alpha, inflammation related genes COX2 and iNOS, and an apoptosis related gene Caspase3 in immune organs of liver, spleen, thymus and Bursa of Fabricius of ducks, and reinforce duck natural immunity reactions and disease resistance.

Description

technical field [0001] The invention belongs to the technical field of agriculture and relates to a duck natural immune enhancer based on pattern recognition receptor (PRRs) ligands. Background technique [0002] With the rapid development of my country's animal husbandry, especially the popularization and promotion of large-scale and intensive breeding methods, animal diseases have diversified, and the hazards of animal infectious diseases, especially viral infectious diseases, have become increasingly prominent, which not only seriously affect animal production. , and may threaten human health. Immunoprophylaxis and drug therapy are important means to prevent and control animal infectious diseases. Although they have played an important role, because: ① some viruses have multiple subtypes, and the virus antigens are easy to drift and switch (such as avian influenza virus); ② Under the pressure of the body's immunity and environment, some viruses mutate continuously, and ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113A61K31/711A61P37/04
CPCA61K31/711A61P37/04C12N15/113C12N2310/10
Inventor 李国勤卢立志顾天天田勇陈黎曾涛沈军达陶争荣杜雪徐坚
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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