Method for constructing porous structure on surface of polyether ether ketone scaffold

Abstract

The invention relates to a method for constructing a porous structure on a surface of a polyether ether ketone scaffold. The method mainly comprises the following steps: A, preparing hard particles, concretely pulverizing a hard material, and carrying out sieving to obtain hard particles with a particle size of 200-800 microns; B, embedding the hard particles, concretely adhering the hard particles to the surface of the polyether ether ketone scaffold, placing the polyether ether ketone scaffold in a hot press, then carrying out heating to 170-190 DEG C, keeping the temperature for 1.5-2.5 h,and then applying pressure of 2-4Mpa to obtain the polyether ether ketone scaffold with the hard particles embedded on the surface; and C, carrying out acid etching treatment, concretely placing the polyether ether ketone scaffold prepared in the step B in a hydrofluoric acid solution for 44-52h, removing the hard particles by etching, and then carrying out cleaning to obtain the porous structure.The number and size of the porous structures obtained on the surface of the polyether ether ketone scaffold by the method can be controlled. After the scaffold is implanted into a human body, growthof bone tissues into the scaffold is facilitated, and bone integration performance is good. In addition, mechanical performance is good, and the scaffold structure is stable.

Description

technical field [0001] The invention relates to a method for constructing a porous structure on the surface of a support. Background technique [0002] Polyether ether ketone is a semi-crystalline thermoplastic polymer, which is widely used in trauma and plastic surgery because of its mechanical properties similar to those of human cortical bone, good biocompatibility, and radiolucency. Surgical and spinal implants (Kurtz S M, Devine J N. PEEK biomaterials in trauma, orthopedic, and spinal implants [J]. Biomaterials, 2007, 28(32): 4845-4869.). However, PEEK is biologically inert, and it is difficult to form a good osseointegration with the surrounding bone tissue after the PEEK stent is implanted, which often leads to implant failure. In order to solve this problem, a porous structure is often constructed on the scaffold to provide a growth space for the surrounding tissue to grow into the scaffold, so as to promote good osseointegration of the scaffold and the surrounding ...

AI Technical Summary

Problems solved by technology

[0005] However, since the pore-forming agent is embedded in the extrusion cooling molding process of the stent, the embedding time is short, and the temperature of the material during embedding is difficult to control accurately; and the stent material itself is in the process of extrusion during embedding, which inevitably leads to some The pore-forming agent (sodium chloride) is embedded too deeply into the scaffold, and part of the pore-forming agent cannot be embedded on the surface of the scaffold, resulting in uncontrollable porous structure of the scaffold and poor osseointegration performance

The pore-forming agent embedded too deeply inside the scaffold may be incompletely leached during leaching, which will lead to unstable scaffold structure

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