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Preparation method of glucosamine sulfate potassium salt

A technology of glucosamine sulfate potassium salt and lactic acid glycine hydrochloride, which is applied in the field of medicine and chemical industry, can solve the problems of instability and high hygroscopicity of glucosamine sulfate, and achieve the effect of low cost and simple process

Active Publication Date: 2020-01-31
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is in order to overcome the deficiency of above-mentioned background technology, a kind of preparation method of glucosamine sulfate potassium salt is provided, the glucosamine sulfate potassium salt that makes in the method has high purity, good stability, is difficult to be oxidized, overcomes The pure glucosamine sulfate has the defects of high hygroscopicity and instability, and is suitable for medicinal use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 1kg chitin powder, add 2.5L lactic acid glycine hydrochloride and 0.85L hydrochloric acid with a mass concentration of 32%, stir and mix at 43°C, and then use a diaphragm pump to continuously pump into a microporous membrane filter for filtration to obtain Filtrate; the resulting filtrate was heated to 68°C, kept warm and added dropwise with hydrochloric acid with a mass concentration of 25%, stirred for 15 minutes, after cooling, added activated carbon for decolorization, concentrated, washed, and dried to obtain glucosamine hydrochloride; add to the obtained glucosamine hydrochloride Add potassium sulfate aqueous solution, heat to 60°C, add acetone, cool to 30°C, stir for 15-20 hours to make the material fully react; cool the reacted material to -5°C, crystallize under stirring conditions, and then separate Obtain white crystals; dry the centrifuged white crystals under vacuum conditions at a temperature of 35°C to 50°C to obtain glucosamine sulfate potassium salt...

Embodiment 2

[0027] Take 1kg of chitin powder, add 3.0L lactic acid glycine hydrochloride and 1.0L hydrochloric acid with a mass concentration of 30%, stir and mix at 45°C, and then use a diaphragm pump to continuously pump into a microporous membrane filter for filtration to obtain Filtrate; the obtained filtrate was heated up to 70°C, kept warm and added dropwise with hydrochloric acid with a mass concentration of 28%, stirred for 10 minutes, after cooling, added activated carbon for decolorization, concentrated, washed, and dried to obtain glucosamine hydrochloride; add to the obtained glucosamine hydrochloride Add potassium sulfate aqueous solution, heat to 65°C, add acetone, cool to 35°C, stir for 15-20 hours to make the material fully react; cool down the reacted material to 0°C, crystallize under stirring, and then centrifuge to obtain White crystals; dry the centrifuged white crystals under vacuum conditions at a temperature of 35°C to 50°C to obtain glucosamine sulfate potassium sa...

Embodiment 3

[0029] Take 1kg of chitin powder, add 2.0L lactic acid glycine hydrochloride and 1L hydrochloric acid with a mass concentration of 35%, stir and mix at 40°C, and then use a diaphragm pump to continuously pump it into a microporous membrane filter for filtration to obtain the filtrate The resulting filtrate was heated to 65°C, kept warm and added dropwise hydrochloric acid with a mass concentration of 23%, stirred for 17 minutes, added activated carbon to decolorize after cooling, concentrated, washed, and dried to obtain glucosamine hydrochloride; to the obtained glucosamine hydrochloride, add Potassium sulfate aqueous solution, heated to a temperature of 50°C, adding acetone, cooling to 25°C, stirring for 15-20 hours to allow the material to fully react; cooling the reacted material to -10°C, crystallizing under stirring, and centrifuging to obtain White crystals; dry the centrifuged white crystals under vacuum conditions at a temperature of 35°C to 50°C to obtain glucosamine ...

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Abstract

The invention belongs to the field of medicine and chemical industry, and discloses a preparation method of glucosamine sulfate potassium salt. The preparation method comprises the following steps: adding lactic acid glycine hydrochloride and hydrochloric acid into chitin powder, stirring and mixing, and filtering to obtain a filtrate; heating, preserving heat, dropwise adding hydrochloric acid, stirring, cooling, decoloring the solution, concentrating, washing and drying to obtain glucosamine hydrochloride; adding a potassium sulfate aqueous solution, heating, adding an organic solvent, cooling to 25 DEG C to 35 DEG C, fully reacting, cooling, crystallizing, centrifuging to obtain a white crystal, and drying to obtain the glucosamine sulfate potassium salt. According to the preparation method, the high-purity glucosamine hydrochloride is obtained firstly, then the potassium sulfate aqueous solution is added to prepare the glucosamine sulfate potassium salt, and the glucosamine sulfatepotassium salt of which the purity reaches up to 99.95% or more is obtained through crystallization purification and separation, so that the whole technical process is simple, low in cost, environmentally-friendly and economical, and the preparation method is suitable for large-scale popularization and application.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a preparation method of glucosamine sulfate potassium salt. Background technique [0002] Amino sugars are generally used as monosaccharide residues in complex oligosaccharides and polysaccharides, and glucosamine is an amino derivative of the monosaccharide glucose. Glucosamine can significantly relieve the pain of arthritis and rheumatism patients and improve, prevent, treat and repair connective tissue damage. It also has a certain effect on bone and arthritis inflammation, and it also helps the healing of acute and chronic inflammation. Therefore, it is beneficial to the heart It also has a certain curative effect to inhibit the excessive growth of cancer cells or fibroblasts, and plays an inhibitory and therapeutic role in cancer and malignant tumors. [0003] Glucosamine in the prior art mainly includes two types of glucosamine hydrochloride and glucosamine su...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H1/06C07H5/06
CPCC07H1/00C07H1/06C07H5/06
Inventor 卢健行韩宁卢建功刘长峰卢建智吴祥舟
Owner SHANDONG RUNDE BIOTECH CO LTD
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