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Traditional Chinese medicinal external composition containing recombinant hirudin for treating chloasma and preparation method of traditional Chinese medicinal external composition

A composition for external use, recombinant hirudin technology, applied in the direction of drug combination, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problem of slow onset of action, increased burden on the intestinal tract and liver, and bitter taste and other problems, to achieve stable physical and chemical properties, prolong storage time, and good storage stability

Inactive Publication Date: 2020-02-04
上海松皓生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some traditional Chinese medicines need to be taken orally, which have problems such as bitter taste, slow onset, and increased burden on the intestinal tract and liver.

Method used

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  • Traditional Chinese medicinal external composition containing recombinant hirudin for treating chloasma and preparation method of traditional Chinese medicinal external composition
  • Traditional Chinese medicinal external composition containing recombinant hirudin for treating chloasma and preparation method of traditional Chinese medicinal external composition

Examples

Experimental program
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Effect test

preparation example Construction

[0042] (1) Soak the preparation raw materials of the Chinese medicine components in cold water, and dry them for subsequent use;

[0043] (2) Put the product obtained in step (1) into distilled water for cooking, filter to obtain filtrate and filter residue, and concentrate the filtrate to obtain component A extract;

[0044] (3) Put the filter residue in step (2) into the mixed solution of ethanol\distilled water, reflux extraction, and concentrate to obtain the B component extract, to get final product, the volume ratio of the ethanol and distilled water is 1:(3~5 ).

[0045] angelica

[0046] This product is the dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae. Excavate in late autumn, remove fibrous roots and silt, and after the water evaporates slightly, bundle them into small handles, put them in a shed, and slowly smoke them to dry with fireworks. Dried root of Umbelliferae Angelica sinensis (Oliv,) Diels. Excavate in late autumn, remove fibrous roots a...

Embodiment 1

[0163] Embodiment 1 of the present invention provides a traditional Chinese medicine external application composition containing recombinant hirudin for the treatment of chloasma. Recombinant hirudin fermentation broth, 1.2% of traditional Chinese medicine components, 0.7% of auxiliary agents and the rest of water;

[0164] The raw materials for the preparation of traditional Chinese medicine components include component A and component B, the weight ratio of component A to component B is 1:1; component A includes angelica, Chuanqiong, safflower, bellflower, Bupleurum, Including Citrus aurantium, licorice, motherwort, peach kernel; the weight ratio of angelica, Chuanqiong, safflower, platycodon, Bupleurum is 1:1:1:1; the weight ratio of Citrus aurantium, licorice, motherwort, peach kernel is 1:1: 1:1;

[0165] The water phase components include arginine, small molecule alcohol and complexing agent; the weight ratio of small molecule alcohol to complexing agent is 1:0.005; the...

Embodiment 2

[0203] Embodiment 2 of the present invention provides a traditional Chinese medicine external application composition containing recombinant hirudin for the treatment of chloasma. Recombinant hirudin fermentation broth, 2% of traditional Chinese medicine components, 1% of auxiliary agents and the rest of water;

[0204] The raw materials for the preparation of traditional Chinese medicine components include component A and component B, the weight ratio of component A to component B is 1:1.2; component A includes angelica, Chuanqiong, safflower, bellflower, Bupleurum, Including citrus aurantium, licorice, motherwort, peach kernel; the weight ratio of angelica, chuanqiong, safflower, bellflower, Bupleurum is 1:1.2:1.2:1.2; the weight ratio of aurantium, licorice, motherwort, peach kernel is 1:1.2: 1.2: 1.2; The preparation method of the Chinese medicine component is the same as in Example 1;

[0205] The water phase components include arginine, small molecule alcohol and comple...

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Abstract

The present invention relates to the related field of treating melisma and more specifically provides a traditional Chinese medicinal external composition containing recombinant hirudin for treating melasma and a preparation method of the traditional Chinese medicinal external composition. The provided traditional Chinese medicinal external composition containing the recombinant hirudin for treating the melisma comprises the following preparation raw materials in weight percentages: 3-15% of an aqueous phase component, 0.5-3% of an oil phase component, 3-12% of recombinant hirudin fermentationliquid, 0.5-2% of traditional Chinese medicine components, 0.1-1% of an adjuvant and the balance water; wherein the aqueous phase component comprises arginine. Compared with the prior art, the provided traditional Chinese medicinal external composition for treating the melasma is prepared by a method for combining the recombinant hirudin fermentation liquid and the traditional Chinese medicine components, has a better therapeutic effect for different age groups, also has stable physical and chemical properties and relatively good storage stability, and is relatively well prolonged in storagetime.

Description

technical field [0001] The invention relates to the related field of treating chloasma, more specifically, the invention provides a traditional Chinese medicine external application composition containing recombinant hirudin for treating chloasma and a preparation method thereof. Background technique [0002] Melasma is a common facial hyperpigmented skin disease, and its skin lesions are symmetrical, well-defined light brown, coffee-colored or light black patches. The disease mainly occurs in young and middle-aged women, and it is a chronic process. The course of the disease is stubborn, lingering and difficult to heal, which seriously affects the patient's appearance and brings a lot of troubles and pains to their spirit and life. The incidence rate of this disease has been very high. In recent years, due to the influence of various factors, its incidence has been increasing year by year, and the number of patients is increasing. With the change of people's living environ...

Claims

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Application Information

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IPC IPC(8): A61K38/58A61P17/00A61K36/752A61K36/8998
CPCA61K9/0014A61K36/076A61K36/232A61K36/233A61K36/236A61K36/284A61K36/286A61K36/344A61K36/346A61K36/484A61K36/533A61K36/736A61K36/752A61K36/8905A61K36/8994A61K36/8998A61K38/58A61K47/183A61P17/00A61K2300/00
Inventor 杨爱岗
Owner 上海松皓生物科技有限公司
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