Tuna red meat ACE inhibitory peptide and preparation method thereof

A tuna and inhibitory peptide technology, applied in the field of tuna red meat ACE inhibitory peptide and preparation thereof, can solve the problems of high cost of blood pressure-lowering peptide, unsuitable for industrial production, low blood pressure lowering activity, etc., and achieves good inhibitory activity and low preparation cost. , the effect of high efficiency
CN110759965AActive Publication Date: 2020-02-07舟山领鲜海洋生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
舟山领鲜海洋生物科技有限公司
Publication Date
2020-02-07

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Abstract

The invention provides tuna red meat ACE inhibitory peptide and a preparation method thereof, and relates to the field of preparation of ACE inhibitory peptide. The peptide fragment amino acid sequences of the tuna red meat ACE inhibitory peptide are Met-Trp-Asn, Met-Glu-Lys-Ser, Met-Lys-Lys-Ser or Leu-Pro-Arg-Ser. The preparation method comprises the following steps of (1) unfreezing the tuna redmeat, performing drying and performing degreasing for standby application; (2) performing enzymolysis on red meat powder after pretreatment to obtain enzymatic hydrolysate; (3) performing enzyme deactivation treatment on the enzymatic hydrolysate to obtain enzyme deactivation enzymatic hydrolysate, performing freeze drying to obtain polypeptide powder, and testing ACE inhibitory activity; and (4)subsequently, performing ultrafiltration, performing column chromatography, performing high efficiency liquid phase chromatographic purification, and performing amino acid sequencing to prepare the tuna red meat ACE inhibitory peptide. The prepared tuna red meat ACE inhibitory peptide is good in inhibitory activity, low in preparation cost, high in efficiency and suitable for industrial production.
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Description

technical field

[0001] The invention relates to the field of preparation of ACE inhibitory peptides, in particular to a tuna red meat ACE inhibitory peptide and a preparation method thereof. Background technique

[0002] The occurrence of hypertension is closely related to the disorder of renin-angiotensin system (RAS) and kallikrein-kinin system (KKS). Angiotensin-converting enzyme plays a role in regulating blood pressure by converting angiotensin Ⅰ (Ang Ⅰ) into the octapeptide angiotensin Ⅱ (Ang Ⅱ ), which has a potent vasoconstrictive effect, and by degrading bradykinin, which has a vasodilation effect. critical use. Antihypertensive peptides can form competitive inhibition on the substrate of angiotensin-converting enzyme, and affect the generation of Ang II, which has a strong vasoconstrictive effect, so as to achieve the purpose of lowering blood pressure. Therefore, angiotensin-converting enzyme inhibition plays an important role in antihypertensive drugs target. ...

Claims

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