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Micron-nanometer structural bionic scaffold and preparation method

A hierarchical structure, micro-nano technology, applied in the field of biomedicine, can solve problems such as the inability to change the interaction mode, achieve good mechanical properties, and promote osteogenesis.

Inactive Publication Date: 2020-02-11
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, adding inorganic salts did not change the material's mode of interaction with cells

Method used

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  • Micron-nanometer structural bionic scaffold and preparation method
  • Micron-nanometer structural bionic scaffold and preparation method
  • Micron-nanometer structural bionic scaffold and preparation method

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preparation example Construction

[0028] The invention provides a preparation method of a micro-nano grade structure bionic support, comprising:

[0029] 1) Mix the bioactive glass nanoparticles with the silk fibroin solution and perform ultrasonic oscillation, and obtain the silk fibroin porous scaffold reinforced by the bioactive glass nanoparticles by freeze-drying after pre-freezing;

[0030] 2) Drop the collagen solution onto the porous silk fibroin scaffold reinforced with bioactive glass nanoparticles prepared in step 1) and place it in a suitable environment for self-assembly to obtain a biomimetic scaffold with a micro-nano scale structure.

[0031] According to the present invention, the present invention mixes bioactive glass nanoparticles and silk fibroin solution for ultrasonic reaction to obtain a silk protein porous scaffold reinforced by bioactive glass nanoparticles; wherein, the mass concentration of the silk fibroin solution is preferably 4-8w / w%, more preferably 6-7w / w%; the mass ratio of ...

Embodiment 1

[0042] (1) Preparation of silk fibroin solution and mesoporous bioactive glass nanoparticles.

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Abstract

The invention provides a micron-nanometer structural bionic scaffold. Through the application of self-assembled collagen nano-fibers and bioactive glass nano-particles, strengthening can be performedon a scaffold respectively from the pores and the skeleton of a micron-sized silk fibroin porous scaffold, so that the micron-nanometer structural bionic scaffold strengthened on both inside and outside can be built. Through the discovery of experiments, the obtained bionic scaffold can have excellent mechanical properties, the collagen nano-fibers, the bioactive glass and silk fibroin can be stably integrated, and the osteogenesis of stem cells can be better promoted through the bionic structure of the bionic scaffold.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a bionic scaffold with a micro-nano scale structure and a preparation method thereof. Background technique [0002] At present, the construction of biological scaffolds for promoting bone regeneration mainly revolves around two basic strategies: namely, adding active ingredients to the scaffolds or regulating the structural morphology of the scaffolds. With the advancement of bioactive factor synthesis technology and stem cell therapy technology, biomaterial scaffolds can achieve good bone regeneration effects by adding bioactive factors, inorganic salts, and stem cells with regenerative capabilities. However, due to the application of exogenous bioactive components, problems such as uncontrolled regeneration and potential cancer risk have been caused. In contrast, although structural factors promote osteogenesis have been partially studied, the effect of promoting osteogenesis is not...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/10A61L27/22A61L27/50A61L27/56
CPCA61L27/10A61L27/227A61L27/24A61L27/50A61L27/56A61L2400/12A61L2430/02C08L89/00
Inventor 陈亮顾勇唐锦程毛剑楠吴亮崔文国
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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