System and method for detecting ectopic pregnancy

An ectopic pregnancy, subject technology, applied in biological testing, material testing products, health index calculation, etc., can solve the problem of ectopic pregnancy rupture not being detected in time

Active Publication Date: 2020-02-18
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the clinical symptoms and signs of ectopic pregnancy such as abdominal pain and vaginal bleeding are non-specific, which can easily lead to the failure of timely detection of ectopic pregnancy rupture

Method used

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  • System and method for detecting ectopic pregnancy
  • System and method for detecting ectopic pregnancy
  • System and method for detecting ectopic pregnancy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] In the example, based on 6612 fresh embryo transfers (with IVF / ICSI-ET protocol) performed in Peking University Third Hospital from December 2015 to June 2016, and the basic data of 6612 patients who received embryo transfers were recorded Characteristics, basic sex hormone level, number of antral follicles, primary and secondary, and 5 main factors of infertility (the 5 main factors of infertility in this application refer to: factor 1, male factor; factor 2 , endometriosis; factor 3, ovulatory disturbance; factor 4, fallopian tube factor; and factor 5, unexplained infertility and others), endometrial thickness and morphology classification, controlled ovarian stimulation protocol (described in detail below) , the number of previous IVF / ICSI-ET cycles (that is, several test tube cycles in the past), the number of oocytes with a diameter > 18mm obtained by ovulation induction, insemination method, insemination date, embryo transfer date, embryo transfer number, embryo tr...

Embodiment 2

[0181] Embodiment 2 single factor analysis

[0182] For the statistical data of the 1650 patients mentioned above, a univariate analysis was first performed to explore the relationship between the respective variables and ectopic pregnancy. hCG 14 , hCG 21 , FC, and transplantation methods were all statistically significant. At this time, the model results are shown in Table 1 below, where the factors with P14 , hCG 21 , FC, transplantation method, and multivariate analysis was performed based on these factors.

[0183] Table 1 Single factor analysis results

[0184]

Embodiment 3

[0185] Embodiment 3 establishes prediction model

[0186] The 6 variables determined in the above-mentioned Example 2, i.e. infertility factors (hereinafter sometimes expressed by cause), endometrial thickness, hCG 14 , hCG 21 , FC=hCG 21 / hCG 14 , The transplantation method is incorporated into the model, and the prediction model is established. In addition, since hCG 14 and hCG 21 Highly correlated, cannot be included in the model at the same time, only one of them can be selected, in the model of Example 3, hCG is selected 21 level into the model.

[0187] The process of establishing the prediction model is as follows: first, the data of the above five variables are divided into a training set and a verification set, each accounting for 75% and 25% of the samples. Then model in the training set and verify in the verification set. The verification method uses logistic regression based on 5-fold cross-validation based on the forward method, and the index uses the scale...

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Abstract

The invention relates to a system for detecting ectopic pregnancy. The system comprises: a data acquisition module used for acquiring data of a 14th-day hCG level (hCG14) after embryo transplantationof a subject and a 21st-day hCG level (hCG21) after embryo transplantation of the subject, and acquiring data of main infertility factors of the subject; a data processing module used for further processing the data acquired in the data acquisition module; and a module used for calculating the probability of ectopic pregnancy by utilizing the data processed in the data processing module so as to calculate the probability of ectopic pregnancy of the subject after in-vitro insemination embryo transplantation or clear ovulation period natural pregnancy, and determining the probability grouping ofectopic pregnancy of the subject based on a calculation result.

Description

technical field [0001] The present invention relates to a system and method for detecting ectopic pregnancy (ectopic pregnancy), in particular to a system and method for predicting the probability of ectopic pregnancy in a subject after adopting IVF / ICSI-ET technology . Background technique [0002] Ectopic pregnancy (EP), also known as ectopic pregnancy, is a major cause of maternal morbidity and mortality in the first trimester, manifested by the occurrence of a fertilized egg elsewhere than in the uterus. The incidence of ectopic pregnancy due to assisted reproductive technology (ART) is 2-3 times higher than spontaneous pregnancy. However, the clinical symptoms and signs of ectopic pregnancy such as abdominal pain and vaginal bleeding are non-specific, which can easily lead to the failure to detect the rupture of ectopic pregnancy in time. Ectopic pregnancy-induced deaths account for 5% to 10% of all maternal deaths. Contents of the invention [0003] Ectopic pregna...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G01N33/76
CPCG01N33/76G16H50/30
Inventor 李蓉徐慧玉乔杰冯国双韩勇
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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