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Preparation method of hydrogel for targeted treatment of cancer cells

A targeted therapy, cancer cell technology, applied in cell dissociation methods, tumor/cancer cells, biochemical equipment and methods, etc., can solve the problems of tissue toxicity, damage, multidrug resistance, etc. , make simple effects

Inactive Publication Date: 2020-02-21
KUNSHAN BYE MACROMOLECULE MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the clinical treatment of cancer is mainly through Western medicine surgery, radiotherapy and chemotherapy combined with traditional Chinese medicine. Tissues will also produce greater toxic side effects or damage. At the same time, tumor cells are prone to multidrug resistance to chemotherapy drugs, triggering autoimmune reactions to clear drugs or block their efficacy. Magnetic nanoparticles are developing rapidly and are widely used in In terms of biomarking and separation, nuclear magnetic resonance imaging (MRI), tissue repair, drug carriers, and disease diagnosis and treatment, magnetic nano-Fe3O4 particles are easy to make and crystals are non-toxic to cells. They are the most magnetic minerals in nature and can meet the needs of biological Many medical requirements are widely applied to the biomedical field by scientists

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The invention provides a method for preparing a hydrogel for targeted treatment of cancer cells, comprising the following steps:

[0020] S1, mixing acrylic acid and Fe3O4 magnetic nanoparticles in a molar ratio of 1:1 in a mixing device;

[0021] S2, then reacting in the reactor at 35°C for 10 minutes to combine acrylic acid and Fe3O4 magnetic nanoparticles to obtain a composite hydrogel;

[0022] S3, finally taking the anticancer drug doxorubicin and wrapping it in the composite hydrogel obtained in step S2;

[0023] S4. Complete the preparation of the hydrogel for targeted therapy of cancer cells.

[0024] Specifically, the composite hydrogel obtained by combining acrylic acid and Fe3O4 magnetic nanoparticles in step S2 can be released quickly to achieve the effect of targeted treatment of cancer cells.

[0025] Specifically, the use of nano-Fe3O4 magnetic materials as targeted drug carriers can bind drug molecules on the one hand and protect drug molecules on the ...

Embodiment 2

[0030] The invention provides a method for preparing a hydrogel for targeted treatment of cancer cells, comprising the following steps:

[0031] S1, mixing acrylic acid and Fe3O4 magnetic nanoparticles in a molar ratio of 1:1 in a mixing device;

[0032] S2, then reacting at 37°C in the reactor for 11 minutes to combine acrylic acid and Fe3O4 magnetic nanoparticles to obtain a composite hydrogel;

[0033] S3, finally taking the anticancer drug doxorubicin and wrapping it in the composite hydrogel obtained in step S2;

[0034] S4. Complete the preparation of the hydrogel for targeted therapy of cancer cells.

[0035] Specifically, the composite hydrogel obtained by combining acrylic acid and Fe3O4 magnetic nanoparticles in step S2 can be released quickly to achieve the effect of targeted treatment of cancer cells.

[0036] Specifically, the use of nano-Fe3O4 magnetic materials as targeted drug carriers can bind drug molecules on the one hand and protect drug molecules on the ...

Embodiment 3

[0041] The invention provides a method for preparing a hydrogel for targeted treatment of cancer cells, comprising the following steps:

[0042] S1, mixing acrylic acid and Fe3O4 magnetic nanoparticles in a molar ratio of 1:1 in a mixing device;

[0043] S2, then reacting at 39°C in the reactor for 12 minutes to combine acrylic acid and Fe3O4 magnetic nanoparticles to obtain a composite hydrogel;

[0044] S3, finally taking the anticancer drug doxorubicin and wrapping it in the composite hydrogel obtained in step S2;

[0045] S4. Complete the preparation of the hydrogel for targeted therapy of cancer cells.

[0046] Specifically, the composite hydrogel obtained by combining acrylic acid and Fe3O4 magnetic nanoparticles in step S2 can be released quickly to achieve the effect of targeted treatment of cancer cells.

[0047] Specifically, the use of nano-Fe3O4 magnetic materials as targeted drug carriers can bind drug molecules on the one hand and protect drug molecules on the ...

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Abstract

The invention belongs to the technical field of hydrogel preparation, and specifically discloses a preparation method of a hydrogel for targeted treatment of cancer cells. The method comprises the following steps: mixing acrylic acid and a Fe3O4 magnetic nanoparticle in mixing equipment according to a molar ratio of 1:1, then carrying out a reaction in a reactor at 35-42 DEG C for 10-15 min for combination of acrylic acid with the Fe3O4 magnetic nanoparticle to obtain a composite hydrogel, and finally wrapping the anticancer drug Adriamycin in the composite hydrogel obtained in step S2. The magnetic nanoparticle is used for a drug carrier and disease diagnosis and treatment, acrylic acid and the Fe3O4 magnetic nanoparticle are combined to form the composite hydrogel, and the anticancer drug Adriamycin is wrapped in the composite hydrogel. The hydrogel can be quickly released to achieve the role of targeted treatment of cancer cells. The nano-Fe3O4 magnetic material as a targeted drug carrier can bind drug molecules on the one hand and protect the drug molecules on the other hand.

Description

technical field [0001] The invention belongs to the technical field of hydrogel preparation, and in particular relates to a preparation method of hydrogel for targeted treatment of cancer cells. Background technique [0002] At present, the clinical treatment of cancer is mainly through Western medicine surgery, radiotherapy and chemotherapy combined with traditional Chinese medicine. Tissues will also produce greater toxic side effects or damage. At the same time, tumor cells are prone to multidrug resistance to chemotherapy drugs, triggering autoimmune reactions to clear drugs or block their efficacy. Magnetic nanoparticles are developing rapidly and are widely used in In terms of biomarking and separation, nuclear magnetic resonance imaging (MRI), tissue repair, drug carriers, and disease diagnosis and treatment, magnetic nano-Fe3O4 particles are easy to make and crystals are non-toxic to cells. They are the most magnetic minerals in nature and can meet the needs of biolo...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K47/02A61K31/704A61P35/00A61L26/00A61K49/18A61K49/12A61K49/08C12Q1/02C12N5/09
CPCA61K9/06A61K31/704A61K47/02A61K47/32A61K49/08A61K49/126A61K49/1803A61L26/00A61L26/0014A61L26/0061A61L26/0066A61L26/008A61P35/00C12N5/0693C12N2509/10G01N33/5005
Inventor 喻四海赵娇娇施法宽张世友
Owner KUNSHAN BYE MACROMOLECULE MATERIAL CO LTD
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