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Blood purification material based on mussel biomimetic chemistry and preparation method thereof

A technology of blood purification and biomimetic chemistry, applied in the fields of biochemical separation and biomedical materials, can solve the problems of low adsorption force and easy falling off of substrates, and achieve the effect of super-universal adhesion and super-strong waterproof adhesion.

Active Publication Date: 2020-02-28
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing substrates used to prepare blood purification materials are porous materials such as carbonized resins and adsorbent resins, and these materials are usually cross-linked structures with few modifiable groups themselves. Aldehyde (PVB) directly coats porous materials such as carbonized resin and adsorption resin, and the formed coating film has a small adsorption force for the substrate and is easy to fall off

Method used

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  • Blood purification material based on mussel biomimetic chemistry and preparation method thereof
  • Blood purification material based on mussel biomimetic chemistry and preparation method thereof

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Effect test

Embodiment 1

[0023] A blood purification material based on mussel biomimetic chemistry. The blood purification material consists of a porous adsorption substrate, an adsorption layer, and a coating film from the inside to the outside. The adsorption layer is a polylysine hydrochloride adsorption layer. In addition, polylysine hydrochloride is wound on the porous adsorption substrate in the form of molecular chains; the coating film is a polyvinyl butyral-gallic acid film; and the porous adsorption substrate is carbonized resin.

[0024] The preparation method of the above-mentioned blood purification material comprises the following steps:

[0025] (1) Coating the polylysine hydrochloride solution on the carbonized resin to form a polylysine hydrochloride adsorption layer, wherein the mass fraction of the polylysine hydrochloride solution is 20%, and the carbonized resin The pore size is 2-50nm, and the specific surface area of ​​the porous adsorption substrate is >500m 2 / g;

[0026] (2...

Embodiment 2

[0028] A blood purification material based on mussel biomimetic chemistry, the blood purification material is sequentially composed of a porous adsorption substrate, an adsorption layer and a coating film from the inside to the outside, the adsorption layer is a polymyxin B sulfate adsorption layer, and Polymyxin B sulfate is wound on the porous adsorption substrate in the form of molecular chains; the coating film is polyvinyl butyral-gallic acid film; and the porous adsorption substrate is carbonized resin.

[0029] The preparation process of the above-mentioned blood purification material comprises the following steps:

[0030] (1) polymyxin B sulfate (PMB) solution is coated on carbonized resin, forms polymyxin B sulfate adsorption layer, and wherein the massfraction of polymyxin B sulfate solution is 5%, described carbonized resin The pore size is 2-50nm, and the specific surface area of ​​the porous adsorption substrate is >500m 2 / g;

[0031] (2) Put the carbonized re...

Embodiment 3

[0033] A blood purification material based on mussel biomimetic chemistry, the blood purification material is sequentially composed of a porous adsorption substrate, an adsorption layer and a coating film from the inside to the outside, the adsorption layer is polyethyleneimine, and polyethyleneimine Wrapped on the porous adsorption substrate in the form of molecular chains; the coating film is polyvinyl alcohol butyral-gallic acid film, and the porous adsorption substrate is polystyrene divinyl adsorption resin.

[0034] The preparation process of the above-mentioned blood purification material comprises the following steps:

[0035] (1) The polyethyleneimine solution is coated on the polystyrene divinylbenzene adsorption resin, and the polyethyleneimine adsorption layer is formed on the polystyrene divinylbenzene adsorption resin, wherein the mass fraction of the polyethyleneimine solution used is 10%, the pore diameter of the polystyrene divinylbenzene adsorption resin is 2...

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Abstract

The invention discloses a blood purification material based on mussel biomimetic chemistry and a preparation method thereof. The blood purification material sequentially comprises a porous adsorptionbase material, an adsorption layer and a coating film from inside to outside, the adsorption layer is one or more of polymyxin B sulfate, polylysine hydrochloride, polyethyleneimine or polydopamine, and the adsorption layer is wound on the porous adsorption base material in a molecular chain form; and the coating film is a polyvinyl butyral-gallic acid film or a polyvinyl butyral film. The blood purification material is designed on the basis of mussel biomimetic chemistry, has the advantages of simplicity, convenience, mild conditions, greenness, environmental protection and basically no influence on material bodies, and is applied to the field of blood purification medical instruments.

Description

technical field [0001] The invention belongs to the field of biochemical separation and biomedical materials, in particular to a blood purification material based on mussel bionic chemistry and a preparation method thereof. Background technique [0002] In the existing preparation process of blood purification medical device materials, it is often necessary to modify the adsorbent. The coating materials usually include PVB, collodion, etc., such as improving blood compatibility through physical coating, or through chemical reaction Solid loading improves its adsorption capacity. However, most of the existing substrates used to prepare blood purification materials are porous materials such as carbonized resins and adsorbent resins, and these materials are usually cross-linked structures with few modifiable groups themselves. Aldehyde (PVB) directly coats porous materials such as carbonized resin and adsorption resin, and the formed coating film has a small adsorption force f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/26B01J20/28B01J20/30B01J20/32B01D15/00
CPCB01J20/24B01J20/262B01J20/261B01J20/28021B01J20/28033B01J20/28083B01J20/28064B01J20/3085B01J20/3202B01J20/3289B01D15/00B01J2220/4856
Inventor 李设桥姜建明
Owner 佛山市博新生物科技有限公司
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