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A method, device and control system for insulin release and recovery

A recovery system, insulin technology, applied in the field of insulin release and recovery, to reduce the frequency, increase availability, and avoid damage

Active Publication Date: 2022-07-26
MINGCHE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So one limitation of these devices is that insulin refills

Method used

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  • A method, device and control system for insulin release and recovery
  • A method, device and control system for insulin release and recovery
  • A method, device and control system for insulin release and recovery

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Example 1: Preparation method of magnetically labeled insulin

[0045] In the present invention, we used EDC / NHS to activate the surface carboxyl group-modified MNPs to react with the amino group of insulin, and achieved good results. Below is our method for labeling insulin with nanomagnetic particles.

[0046] (1) Dissolve 8 mg of EDC and 1 mg of NHS in 2 mL of deionized water, add 2 mL of carboxylated ferric oxide nanoparticles, and stir at room temperature for 20 min.

[0047] (2) Put the stirred small beaker or small centrifuge tube containing the mixed solution on a magnet (or magnetic stirrer) to help the magnetic nanoparticles to precipitate, then pour out the supernatant, add deionized water to wash, Repeat this 2-3 times.

[0048] (3) Add the washed nano-magnetic particles to 5 mL of insulin solution (insulin solution preparation: 5 mg of insulin is dissolved in 1 mL of 0.01 mol / L hydrochloric acid, and then diluted to 5 mL with PBS pH 7.4 - if any precipita...

Embodiment 2

[0054] like Figure 4 As shown, an insulin recovery and release device includes a recovery system I, a magnetic separation system II and a magnetically labeled insulin storage chamber III,

[0055] The recovery system 1 includes: an insulin enrichment tube 3 and an electromagnetic coil I2 arranged around the insulin enrichment tube 3;

[0056] The magnetic separation system II includes: a Y-shaped pipeline, which includes an A inlet 5, a B outlet 7 and a C outlet 8, and a permanent magnet 6 is provided on one side of the B outlet 7 of the Y-shaped pipeline;

[0057] The magnetically labeled insulin storage chamber III comprises: a housing 15, a piston 12 is arranged in the housing 15, an electromagnetic coil III10 is arranged at the left end, and a micromotor 11 is arranged at the right end, and the piston 12 divides the inner space of the housing 15 into a left chamber 17 and a left chamber. The right chamber 18, the piston 12 is provided with a reversing valve 9 that commun...

Embodiment 3

[0061] like Figure 5 As shown, a control system for an insulin recovery and release device includes:

[0062] Blood sugar sensor, used to detect blood sugar concentration in blood;

[0063] The controller is used to receive the blood sugar concentration signal of the blood sugar sensor. When the blood sugar concentration is higher than the set threshold, the electromagnetic coil I and the electromagnetic coil III are not energized, start the micromotor, make the piston reciprocate, and release the magnetically labeled insulin; When the blood glucose concentration is lower than the set threshold, the electromagnetic coil I and the electromagnetic coil III are energized, the micromotor is started, the piston reciprocates, and the magnetically labeled insulin is recovered; when the blood glucose concentration is normal, the electromagnetic coil I and the electromagnetic coil III are not energized, Turn off the micromotor.

[0064] The working principle of the device for insuli...

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Abstract

The invention relates to a method, a device and a control system for releasing and recovering insulin, comprising the following steps: 1) labeling insulin with nano-magnetic particles; 2) selectively releasing the stored insulin; 3) recovering insulin by using a magnetic field; 4) Store the recovered insulin. In this study, based on the understanding of the process of insulin secretion, regulation, and metabolism, it is proposed for the first time to label insulin with superparamagnetic nanoparticles and to recover the insulin that has finished functioning or is idle in the cellular or extracellular environment. Feasibility and Invention of Magnetically Labeled Insulin. Then, based on the adsorption and capture of magnetically labeled insulin and the study of local motion control, a recovery device for magnetically labeled insulin was invented and designed.

Description

technical field [0001] The invention relates to the labeling, release and recovery of human insulin, in particular to a method, a device and a control system for the release and recovery of insulin. The need for refilling of insulin delivery devices. Background technique [0002] With the improvement of people's living standards and the reduction of physical activity, diabetes has become the third most serious chronic non-communicable disease that threatens human health after tumors and vascular diseases. It has grown to 366 million people and is expected to reach nearly 600 million in 20 years, while the number of people with diabetes in China has reached 114 million. Diabetes has the characteristics of high mortality, high disability rate and high medical expenses, and has become a public health problem faced by all countries in the world. [0003] Diabetes, as a lifelong chronic disease, affects our body's ability to regulate blood sugar concentration, which leads to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61P3/10A61M5/145C07K1/13C07K14/62
CPCA61K38/28A61P3/10A61M5/1452C07K14/62
Inventor 殷瑞雪谷元鑫康良发张洪波杨士模章文俊
Owner MINGCHE BIOTECHNOLOGY CO LTD