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Synthetic method of R<1>R<2>PCl

A synthesis method and phosphine technology, which is applied in the field of synthesis of chlorophosphine, can solve the problems such as difficulty in obtaining pure products, and achieve the effects of low toxicity, less by-products and high conversion rate

Active Publication Date: 2020-03-27
ZHEJIANG YANGFAN NEW MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of this method is that it requires a large amount of PCl 3 (equivalent to R 1 R 2 10 times the equivalent of P(O)H, PCl 3 Also used as solvent), and it is difficult to obtain pure product, its chemical reaction formula is as follows:

Method used

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  • Synthetic method of R&lt;1&gt;R&lt;2&gt;PCl
  • Synthetic method of R&lt;1&gt;R&lt;2&gt;PCl
  • Synthetic method of R&lt;1&gt;R&lt;2&gt;PCl

Examples

Experimental program
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Effect test

Embodiment 1

[0030] In a sealed NMR tube filled with argon, the Ph 2 P(O)H (0.05mmol) was dissolved in 0.5mL of solvent tetrahydrofuran, and acetyl chloride was added (the amount of acetyl chloride was Ph 2 2 equivalents of P(O)H), and the mixture was reacted at 25°C for 12 hours, and the yield was 95%.

Embodiment 2

[0032] In a sealed NMR tube filled with argon, the Ph 2 P(O)H (0.05mmol) was dissolved in 0.5mL of solvent tetrahydrofuran, and acetyl chloride was added (the amount of acetyl chloride was Ph 2 1 equivalent of P(O)H), and the mixture was reacted at 25° C. for 12 hours, and the yield was 66%.

Embodiment 3

[0034] In a sealed NMR tube filled with argon, the Ph 2 P(O)H (0.05mmol) was dissolved in 0.5mL of solvent tetrahydrofuran, and acetyl chloride was added (the amount of acetyl chloride was Ph 2 1.2 equivalents of P(O)H), and the mixture was reacted at 100° C. for 12 hours, and the yield was 99%.

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Abstract

The invention provides a synthetic method of R<1>R<2>PCl, and belongs to the field of organic matter synthesis. The synthetic method of R<1>R<2>PCl solves the problems of low reaction yield and the like in the existing R<1>R<2>PCl synthesis, and is characterized in that R<1>R<2>P(O)H is dissolved in an organic solvent and then reacts with acetyl chloride to obtain the R<1>R<2>PCl, and the chemicalreaction formula of the R<1>R<2>PCl is shown as a formula (I), wherein R1 and R2 are aryl and alkyl. The synthetic method has the advantages of the high yield and the like.

Description

technical field [0001] The invention belongs to the field of organic compound synthesis, in particular to a method for synthesizing phosphine chloride. Background technique [0002] Chlorophosphine (R 1 R 2 PCl) is the key raw material for the synthesis of trivalent phosphine compounds, R 1 R 2 PCl is widely used as a reagent in organic synthesis and as a ligand in metal catalysis. For example, R 1 R 2 Alkylation of PCl compounds with organolithium or Grignard reagents is a general method for preparing a series of monodentate or bidentate phosphorus ligands. On the other hand, by R 1 R 2 Nucleophilic substitution reactions of PCl with amines and alcohols also readily yield the corresponding phosphonamine and phosphonate ligands. In addition, R 1 R 2 PCl can also be converted to the corresponding alkali metal phosphide R 1 R 2 PM, R 1 R 2 Subsequent substitution reactions of PM with organohalides generate a wide range of trivalent phosphines. [0003] In chlor...

Claims

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Application Information

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IPC IPC(8): C07F9/52C07F9/50
CPCC07F9/52C07F9/509
Inventor 樊彬刘辉范建军
Owner ZHEJIANG YANGFAN NEW MATERIALS