Oxybuprocaine gastroscope lubricating fluid capable of being orally taken, and preparation method of oxybuprocaine gastroscope lubricating fluid capable of being orally taken

Abstract

The invention discloses oxybuprocaine gastroscope lubricating fluid capable of being orally taken, and a preparation method of the oxybuprocaine gastroscope lubricating fluid capable of being orally taken. The lubricant consists of the following raw materials of glycerine, dimeticone, oxybuprocaine, sodium alginate and purified water. The oxybuprocaine gastroscope lubricating fluid capable of being orally taken disclosed by the invention has the following advantages that the oxybuprocaine gastroscope lubricating fluid capable of being orally taken is free from bitter components, and the glycerine is sweet in taste, so that discomfort reactions of nausea, vomiting and the like of a patient can be improved; the defoaming properties are outstanding, so that gastroscopy view fields are clear;the lubricating functions are good, so that mechanical damage to the upper gastrointestinal in the gastroscope inserting process can be reduced; additionally adding bacteriostasis antibacterial agentsis not needed; and the oxybuprocaine gastroscope lubricating fluid capable of being orally taken has synergistic effects in the respects of lubrication, thickening and anaesthesia. Clinical data indicates that the lubricating effects of the oxybuprocaine gastroscope lubricating fluid capable of being orally taken are increased by 12.5% than those of oxybuprocaine gel, the defoaming effects are increased by 50%, under the condition that the dosage of the oxybuprocaine is 33% lower than that of the oxybuprocaine gel the anaesthesia and analgesic effects are increased by 6.9%, and the deliciousrate is increased by 52.8%.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an oral orally available oxybucaine hydrochloride gastroscope lubricating liquid with oxybucaine hydrochloride as an auxiliary function and a preparation method thereof. Background technique [0002] Gastroscopy is currently the most commonly used and reliable method for diagnosing gastrointestinal diseases. It can directly observe the condition of the patient's stomach, which cannot be replaced by other inspection methods. However, patients often experience strong nausea and vomiting during the examination, and some patients even refuse gastroscopy due to fear. In addition, the process of inserting the mirror is also likely to cause complications such as digestive tract damage and pain and discomfort. Before undergoing gastroscopy, patients often involuntarily swallow a large amount of saliva, which produces a certain amount of foam in the stomach. The foam mixes with...

AI Technical Summary

Problems solved by technology

③ The prescription of Obuvacaine Hydrochloride Gel contains brogeramine (benzalkonium bromide), which tastes extremely bitter ("The Latest National Manual of Standards for Pharmaceutical Excipients", edited by Xiao Sanguan, China Medical Science and Technology Electronic Publishing House, July 2006 , page 552), the field of vision is not clear enough (good rate 42.5%)

Its patented formula has the following disadvantages: ① The main purpose of brogeramine is a disinfectant and antiseptic, and it tastes extremely bitter. Oral administration can cause nausea and vomiting, and concentrated solutions can cause esophageal damage or necrosis ("Clinical Medication Notes Chemical Drugs and Biological Products Volume" Pharmacopoeia 2010 Edition , page 1203), shaking easily produces a lot of foam, not suitable for oral administration

② No defoamer, no lubricant, which affects the clarity of gastroscopy and the lubrication effect when the gastroscope is inserted

③Disodium edetate is mainly used as a chelating agent, but there is no chelated metal ion in the prescription, so the use is not very clear

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