Fluorescent probe for detecting peroxynitrite ions, preparation method and applications thereof

A technology of peroxynitrite and fluorescent probes, which is applied in the field of analytical chemistry, can solve the problems of difficult measurement of peroxynitrite ions, short lifetime of peroxynitrite ions, and low steady-state concentration, and achieve good fluorescence The effect of emission spectrum characteristics, easy promotion, and low preparation cost
CN110964022AInactive Publication Date: 2020-04-07UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2020-04-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a fluorescent probe for detecting peroxynitrite ions. The fluorescent probe provided by the invention has high specificity, is not interfered by other components in a corresponding peroxynitrite ion detection process, can be used for real-time determination of peroxynitrite ions in living cells, amd has wide application prospect. The fluorescent probe for detecting the peroxynitrite ions in cells is high in sensitivity and good in fluorescence emission spectrum characteristic, wherein the peroxynitrite ions in cells are determined by drawing a standard curve, so that thepurpose of rapid and accurate detection of the peroxynitrite ions in the cells can be achieved.
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Description

technical field

[0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a fluorescent probe for detecting peroxynitrite ions and an application thereof. Background technique

[0002] In addition to normal physiological functions, nitric oxide is also related to some cell and tissue damage. Available evidence indicates that the product of the reaction of nitric oxide with superoxide anion is peroxynitrite ion (ONOO-). On the one hand, peroxynitrite ion can play an auxiliary regulatory role in the body's immune system. On the other hand, peroxynitrite ion is a strong oxidizing and potent cytotoxic substance, which is the cause of pathological effects of nitric oxide, which can cause DNA damage, enzyme inhibition, cell death and bacterial poisoning and can cause a range of diseases. At present, it has been found that peroxynitrite ion exists in septic shock, ischemia-reperfusion injury, atherosclerosis, diabetes, Alzheimer's ...

Claims

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