Application of a Nano-Oxygen Free Radical Water in Anticancer Drugs

A technology of anticancer drugs and free radicals, which is applied in the direction of making drugs into special physical or ingestible devices, adding substances to water/sewage treatment, etc., and can solve problems such as the difficulty of increasing the amount of dissolved gas and the difficulty of nano-bubbles , to achieve the effect of improving cellular respiration, promoting metabolism, and being convenient and safe to carry

Active Publication Date: 2022-08-02
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, in the method of generating nanobubbles by disintegrating microbubbles, there is a problem that the gas once dissolved in the liquid will be released from both the gas and liquid due to the sharp temperature rise and shock waves generated when the microbubbles disintegrate. Therefore, it is difficult to increase the amount of gas dissolved in the liquid. Moreover, since the shock wave generated when the micro-bubbles disintegrates is continuously amplified, the amplified shock wave further causes the disintegration of the nano-bubbles themselves, maintaining the generated nano-bubbles. bubbles are very difficult

Method used

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  • Application of a Nano-Oxygen Free Radical Water in Anticancer Drugs
  • Application of a Nano-Oxygen Free Radical Water in Anticancer Drugs
  • Application of a Nano-Oxygen Free Radical Water in Anticancer Drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0070] In a room at 20°C, introduce 4L of pure water into the pure water tank, start the working state, adjust the gas volume control valve, and pass through the gas explosion plate with about 3 million fine holes with an average diameter of 1 μm, and the gas flow is 4000mm. 3 Oxygen with a concentration above 99.7% capacity is discharged at a rate of / min, and the amount of oxygen discharged from the micropores on the gas explosion plate is (μm 3 / min) / (vibration frequency Hz of the vibrator)=33, the vibration radiation with a frequency of 30000 Hz and an amplitude of 1 mm was continuously applied to the ionization device for 2 minutes, and then 0.1 mL of hydrogen peroxide with a concentration of 0.1% was added. The liquid is exported for filling and sealing to obtain nano-oxygen free radical water.

[0071] Among them, the discharge amount of hydrogen (μm3 / min) discharged from the micropores of the gas explosion plate is determined by the control valve ( figure 1 and fig...

Embodiment 2

[0075] In a room at 20°C, introduce 4L of pure water into the pure water tank, start the working state, adjust the gas volume control valve, and pass through the gas explosion plate with about 3 million fine holes with an average diameter of 1.5 μm, and the gas is 4000mm. 3 Oxygen with a concentration above 99.7% capacity is discharged at a rate of / min, and the amount of oxygen discharged from the micropores on the gas explosion plate is (μm 3 / min) / (vibration frequency Hz of vibrator)=100, continuous application of vibration radiation with a frequency of 50000 Hz and an amplitude of 2 mm to the ionization device for 2 minutes to obtain nano-oxygen radical water.

[0076] Among them, the emission of oxygen (μm 3 / min) is controlled by the control valve instrument panel. The ionization device includes a vibrator, and the vibrator applies vibration within an angle range of -15 degrees to 15 degrees with the exhaust surface of the gas explosion plate.

[0077] The obtained nano...

experiment example 1

[0089] Adopt British Malvern (Malvern) nanoparticle tracking recorder to detect, compare the products obtained in Example 1 and Comparative Examples 1-5, and the results are as follows:

[0090] Table 1:

[0091] case Tyndall phenomenon Average diameter of oxygen bubbles Oxygen bubble content half life Penetration Example 1 obvious 100nm 150 million / mL 3 months powerful Comparative Example 1 none not detected none 0 weak Comparative Example 2 none not detected none 0 weak Comparative Example 3 obvious 200nm 80 million / mL 3 months powerful Comparative Example 4 more obvious 230nm 78 million / mL 3 months powerful Comparative Example 5 more obvious 210nm 75 million / mL 3 months powerful

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Abstract

The invention discloses a nano-oxygen free radical water for directional repair of mutant cells and a preparation method thereof, comprising the following steps: discharging oxygen into the water through an air supply device and an air-explosion plate, and performing ionization treatment in the water at the same time to generate oxygen below 200 nm bubbles and oxygen radicals, and wrapping; the liquid is exported for filling and sealing to obtain the nano-oxygen radical water. The ionization treatment is carried out by means of vibration radiation, during the ionization treatment, the amount of oxygen emitted by each micropore of the gas explosion plate is controlled [μm 3 / min] and the vibration frequency [Hz] at the time of ionization is less than or equal to 300. The method of the invention not only realizes the production of oxygen bubbles below 200 nanometers, but also successfully produces new oxygen free radicals and nano oxygen bubbles, and successfully realizes the encapsulation of oxygen free radicals by nano oxygen bubbles.

Description

technical field [0001] The invention belongs to the field of preparation of nanometer oxygen free radical water, in particular to a preparation method of nanometer oxygen free radical water for directional repair of mutant cells. Background technique [0002] The vast majority of life on Earth depends on oxygen to survive and to convert food into energy. Humans are the most typical oxygen-dependent people. [0003] Biological cells have a sensing-stress response mechanism to oxygen concentration. This induction mechanism is called "respiratory state", and the stress mechanism is manifested as adopting different intracellular gene sequencing mechanisms to cope with the changes in the respiratory state. This research has been confirmed by the 2019 Nobel Prize in Medicine. That is, in the normal respiratory state (without hypoxia), the metabolism of cells is in a state of benign gene sorting mechanism and operation mechanism, but when the respiratory state changes (such as h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F1/68A61J3/00
CPCC02F1/68A61J3/00
Inventor 福田浩平解冰
Owner 解冰
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