Oral membrane and preparation method thereof

Abstract

The invention discloses an oral membrane and a preparation method thereof. The oral membrane comprises a drug-loaded adhesive layer, an extension layer and a hydrophobic protection layer which are sequentially arranged in an attached mode. Wherein the drug-loaded adhesive layer is prepared from the following raw materials in parts by weight: 20-40 parts of an adhesive, 0.5-5 parts of a drug-loadedsubstance A, 0.1-1 part of a flavoring agent, 0.1-1 part of essence, 0.5-3 parts of a release agent and 300-600 parts of deionized water; and the extension layer is prepared from the following raw materials in parts by weight: 10-40 parts of an extension agent and 0-5 parts of a drug-loading substance B. The oral membrane can directly act on the affected part of the ulcer, has a drug slow releaseeffect, can relieve pain, promote wound healing and shorten the course of disease, has no side effect and strong adhesive force, can firmly and durably act on the affected part of the oral ulcer, isnot easy to fall off when a patient eats and drinks water, and improves the use comfort of the patient. The preparation method of the oral cavity membrane is simple, low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an oral film and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral ulcer", is the most common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks keratinization Layers or poorer keratosis. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. Therefore, the prevention of oral ulcers is particularly important, and the use of oral preparations to maintain oral hygiene is an important way to prevent the occurrence of oral ulcers. [0003] The existing oral preparations for the treatment of oral ulcers on the m...

AI Technical Summary

Problems solved by technology

The existing oral film is composed of hypromellose. This dosage form can temporarily adhere to the oral ulcer site, but it is water-soluble, easily dissolved by saliva and easily affected by oral movement, the adhesive site is not firm, and the action time not lasting

Although the existing oral patch can firmly adhere to the affected part of the oral cavity, after the patch absorbs water and swells, the foreign body in the oral cavity protrudes and meditates, which is easily affected by oral movement, drinking water and eating; in addition, the commercially available oral patch The area is small, and it cannot effectively protect large-area ulcers

Although the existing oral film glue can effectively protect the oral ulcer surface, has a large area of ​​action, and can adapt to the more complicated oral ulcer surface, it needs the assistance of ethanol solution when used, and the ethanol solution of the oral film glue needs to be glued to the surface during use. Attached to the wound surface, it is easy to stimulate the wound surface of the patient and reduce the adaptability of the patient

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