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A targeted drug-loaded siliceous body and its preparation and application

A siliceous and targeted technology, applied in liposome delivery, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of easy oxidation and weak stability of targeted liposome carriers, and achieve low cost and easy The effect of industrialization and enhanced stability

Active Publication Date: 2019-08-23
上海禾澜纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technical problem solved by the present invention is the problem of weak stability and easy oxidation of the targeted liposome carrier, and it provides a liposome with good stability, high biocompatibility, long sustained release time and large drug loading capacity. , a high-efficiency coating method for drug packaging, and has the advantages of simple process and low cost

Method used

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  • A targeted drug-loaded siliceous body and its preparation and application
  • A targeted drug-loaded siliceous body and its preparation and application
  • A targeted drug-loaded siliceous body and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Pure siliceous body: prepare silicious body by film hydration method, weigh 3mg of siliceous material, acidify it in pH=3 acidic ethanol solution, put it in a 25mL round bottom flask, and add 4ml deionized water after rotary evaporation to dryness. The flask was placed in a constant temperature water bath at 55°C to hydrate the film for about 30 minutes. After ultrasonication in a water bath, the siliceous body suspension can be obtained. Dilute the siliceous body suspension and drop it on the aluminum foil to dry, and the SEM photo of the morphology is shown in the figure.

Embodiment 2

[0030] Pure siliceous body@doxorubicin: Prepare silicious body by thin film hydration method, weigh 3mg of silicious material, acidify it in acidic ethanol solution with pH=3, put it in a 25mL round bottom flask, and after rotary evaporation to dryness, add A certain amount of doxorubicin solution (silica: doxorubicin molar ratio is 30:1) was put into a round bottom flask, and the solvent was removed by slow rotary evaporation (water bath at 55°C, 90r / min), and 4ml of deionized water was added, and the flask Hydrate the film in a constant temperature water bath at 55 degrees Celsius for about 30 minutes. After ultrasonication in the water bath, the siliceous body@doxorubicin suspension can be obtained, and the suspension is added to a centrifuge tube, centrifuged at 6000rpm for 10min, and dialyzed. Remove unencapsulated free doxorubicin in siliceous bodies. The resulting suspension was kept at room temperature in the dark overnight to form a silicate network, and stored in a ...

Embodiment 3

[0032] Targeted siliceous material: The siliceous body is prepared by thin film hydration method, and the molar composition of the prescription is siliceous material / cholesterol / mPEG-DSPE / tumor penetrating peptide-PEG-DSPE=55:45:2:1, and the The components were dissolved in chloroform, and the solvent was removed by rotary evaporation. Weigh 3 mg of the above materials, acidify them in pH=3 acidic ethanol solution, put them in a 25 mL round bottom flask, add 4 ml of deionized water after rotary evaporation, and put the flask in a constant temperature water bath at 55 degrees Celsius to hydrate the film for about 30 minutes. After sonication in a water bath, the targeted siliceous body suspension can be obtained.

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PUM

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Abstract

The invention relates to a targeted medicine-carrying silica body as well as preparation and application thereof. The preparation comprises the steps of synthesizing a silica body raw material, preparing a targeted liposome raw material, and preparing targeted lipid inserted silicon composite body. The application is cross application of a liposome technique and an inorganic particle carrier technique. A synthesized silica body material is composited with the targeted liposome material, silicon is hydrolyzed outside a medicine to form a shell layer, liposome containing different targeted groups forms an outer shell layer, and therefore, the targeting aiming at different tumor tissues is realized by virtue of a composite mechanism. The invention provides a cladding method of the silica body having a targeting effect and the advantages of good stability, high biocompatibility, long slow release time and high drug loading capacity and medicine coating capacity.

Description

technical field [0001] The invention relates to the preparation and application of composite medical materials, relates to a granular material for embedding drugs, a targeted drug-loaded siliceous body and its preparation and application, and is a cross application of liposome technology and siliceous carrier technology . Background technique [0002] Liposome has a bionic cell membrane lipid bilayer structure, enters the body and is swallowed by the reticuloendothelial system to activate the body's autoimmune function, change the distribution of the encapsulated drug in the body, and make the drug in the liver, spleen, lung, bone marrow and other tissues and organs Accumulation in the medium, thereby improving the therapeutic index of the drug, reducing the therapeutic dose of the drug and reducing the toxicity of the drug. Studies have shown that liposome-encapsulated doxorubicin is 50% to 70% less toxic than free doxorubicin. A variety of liposomal drug injections have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/42A61K31/704A61K47/04A61P35/00
Inventor 何丹农严一楠杨迪诚王萍李士浩金彩虹
Owner 上海禾澜纳米科技有限公司
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