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Amphoteric glucan hydrogel and application thereof

A dextran and hydrogel technology, applied in the polymer field, can solve problems such as unreported, and achieve the effects of reducing inflammatory response, good biocompatibility, and soft texture

Inactive Publication Date: 2020-04-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, until now, there have been basically no reports on the application of amphoteric dextran hydrogels in wound dressings.

Method used

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  • Amphoteric glucan hydrogel and application thereof
  • Amphoteric glucan hydrogel and application thereof
  • Amphoteric glucan hydrogel and application thereof

Examples

Experimental program
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Effect test

example 1

[0031] Example 1: Preparation of Dextran Carboxybetaine (Dex-CB) Hydrogel

[0032] The percentages of components are as follows:

[0033] Carboxybetaine glucan content: 40%

[0034] Sodium tetraborate: 5%

[0035] Distilled water: 55%

[0036] Add 1000 mg of carboxybetaine dextran to a glass bottle containing 0.9 mL of deionized water, ultrasonicate for about 30 minutes until completely dissolved, add 0.125 g of sodium tetraborate to 0.5 mL of water, and add it to the amphoteric dextran after heating and dissolving In the carboxybetaine aqueous solution, the pH of the system was adjusted to 9 with 1 mol / L NaOH aqueous solution. After sonication for 5 minutes, a hydrogel was obtained at the bottom of the glass bottle, which had a transparent texture and good flexibility. In order to make the shape of the gel uniform and complete, it is necessary to transfer the precursor solution to a self-made PTFE cylindrical mold before the cross-linking agent and the amphoteric betaine de...

example 2

[0037] Example 2: Preparation of Dextran Carboxybetaine (Dex-CB) Hydrogel

[0038] The percentages of components are as follows:

[0039] Amphoteric carboxybetaine glucan content: 15.9%

[0040] N,N-Methylenebisacrylamide: 2.25%

[0041] Distilled water: 81.85%

[0042] Add 0.113 g of carboxybetaine dextran into a glass bottle containing 0.582 mL of deionized water, ultrasonicate for about 30 minutes until completely dissolved, add 0.016 g of N,N-methylenebisacrylamide, and react at a constant temperature of 50 °C for 30 After 2 minutes, the pH of the system was adjusted to 10 with 2 mol / L NaOH aqueous solution. Ultrasonic cross-linking was performed for 5 minutes to obtain a colorless and transparent gel. In order to make the shape of the gel uniform and complete, it is necessary to transfer the precursor solution to a self-made PTFE cylindrical mold before the cross-linking agent and the amphoteric carboxybetaine-dextran solution are gelatinized, seal it, and place the m...

example 3

[0043] Example 3: Preparation of Dextran Carboxybetaine (Dex-CB) Hydrogel

[0044] The percentages of components are as follows:

[0045] Amphoteric carboxybetaine glucan content: 15.7%

[0046] N,N'-bis(acryloyl)cystamine: 3.88%

[0047] Distilled water: 80.42%

[0048] Add 0.113 g of carboxybetaine dextran into a glass bottle containing 0.578 mL of deionized water, ultrasonicate for 30 minutes until completely dissolved, add 0.028 g of N,N-bis(acryloyl) cystamine, and react at a constant temperature of 50 °C for 30 min, adjust the pH of the system to 10 with 2 mol / L NaOH aqueous solution. Ultrasonic cross-linking was performed for 5 minutes to obtain a colorless and transparent gel. In order to make the shape of the gel uniform and complete, it is necessary to transfer the precursor solution to a self-made PTFE cylindrical mold before the crosslinking agent and the amphoteric betaine solution gel, seal the mold and place it in an oven at 50 °C . The reaction was comple...

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Abstract

The invention provides amphoteric glucan hydrogel and application thereof. The hydrogel is prepared from the following components in percentage by mass: 15 to 40 weight% of zwitterionic glucan; 2-10 wt% of a cross-linking agent and balance of distilled water, wherein the zwitterionic glucan comprises carboxylate betaine glucan and sulfonate betaine glucan. The zwitterionic glucan, the cross-linking agent and the distilled water are uniformly mixed in a centrifuge tube according to the content range of the components, a sodium hydroxide solution is added to adjust the pH value of the system to9-10, and the zwitterionic hydrogel can be obtained through a cross-linking reaction. In order to make the gel form uniform and complete, the precursor solution is transferred into a self-made polytetrafluoroethylene mold to be shaped into a shape with a proper size for wound dressing before gelling. The hydrogel disclosed by the invention is high in water content, so that a wound is in a wet environment; the water absorption capacity is high, secreted body fluid can be absorbed at any time, and excessive hydrops at the wound part is avoided; good biocompatibility is realized, and skin allergy, redness and swelling cannot be caused.

Description

technical field [0001] The invention relates to the technical field of polymers, and relates to an amphoteric glucan hydrogel and its application. In particular, it relates to amphoteric glucan hydrogel compositions and applications for wound dressings. Background technique [0002] The skin is the largest organ of the human body. It acts as the medium of contact between the human body and the external environment, and is also the main natural defense line of the human body. It guards the underlying organs and protects the body from pathogens and microorganisms. Therefore, it is directly affected by harmful microorganisms, heat, mechanics and chemicals. If the skin is damaged and infected by bacteria, the local immunity of the human body will be weakened, the body fluid will be lost, and various complications may be caused. [0003] After the skin is wounded, people will choose appropriate dressings according to the different wounds. The main purpose is to quickly and comp...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08L5/02A61L26/00
CPCC08J3/24C08J3/075A61L26/008A61L26/0023A61L26/0061A61L26/0066C08J2305/02A61L2300/232A61L2300/426C08L5/02
Inventor 魏玉萍邱夏焦琴操礼龙
Owner TIANJIN UNIV
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