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Application of ammonium tetrathiomolybdate in preparation of medicine used for treating renal interstitial fibrosis

A technology of ammonium tetrathiomolybdate and renal interstitial fibrosis, which is applied in the field of medicine and can solve the problems of unreported application of ammonium tetrathiomolybdate and the like

Inactive Publication Date: 2020-05-01
SHANGHAI TONGJI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Prior art: It has been reported that tetrathiomolybdate is used to improve animal lung fibrosis and liver fibrosis, but there is no report about the application of ammonium tetrathiomolybdate of the present invention in the preparation of drugs for the treatment of renal interstitial fibrosis

Method used

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  • Application of ammonium tetrathiomolybdate in preparation of medicine used for treating renal interstitial fibrosis
  • Application of ammonium tetrathiomolybdate in preparation of medicine used for treating renal interstitial fibrosis
  • Application of ammonium tetrathiomolybdate in preparation of medicine used for treating renal interstitial fibrosis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Granules

[0035] The preparation method is as follows:

[0036] (1) Get the crude drug ammonium tetrathiomolybdate to pulverize, sieve and mix;

[0037] (2) Making soft material: mix the bulk drug and granule auxiliary material after the treatment in step (1), and add an appropriate amount of binder to make soft material;

[0038] (3) Wet granules: squeeze the soft material through the screen to get wet granules;

[0039] (4) Drying of granules: use box drying method or fluidized bed drying method;

[0040] (5) Grain sizing and grading: Use the sieving method to carry out sizing and grading to the dried granules in step (4), so that the agglomerated and cohesive granules are dispersed.

Embodiment 2

[0041] Embodiment 2 capsules

[0042] The preparation method is as follows:

[0043] (1) firstly make the empty capsule shell according to the conventional preparation method of the empty capsule shell;

[0044] (2) Preparation of contents: pulverize the raw drug ammonium tetrathiomolybdate to a suitable particle size so that it meets the filling requirements of the hard capsule shell;

[0045] (3) Put the content into the empty capsule shell.

Embodiment 3

[0046] Embodiment 3 oral liquid

[0047] The preparation method is as follows:

[0048] (1) Lixiviation: take the raw material drug ammonium tetrathiomolybdate, wash it, process it into tablets, and build it for 1-2 hours each time, take the juice and leave the residue, then decoct, repeat this 3 times, combine the juice, filter spare;

[0049] (2) purification: adopt enzymatic treatment to carry out purification treatment;

[0050] (3) Concentration: The filtered extract is properly concentrated, and flavoring agents and preservatives can be added as needed. Flavoring agents include honey, simple syrup, glycyrrhizic acid and stevioside, etc., and preservatives include sorbic acid, benzene Formic acid and propionic acid, etc.;

[0051] (4) Subpackaging: Before subpackaging, a certain amount of flavoring agent and preservative is added to the liquid, and after stirring evenly, coarse filtration and fine filtration can be carried out, and put into sterile, clean, dry finger t...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to an application of ammonium tetrathiomolybdate in preparation of a medicine used for treating renal interstitial fibrosis. Novel application of the ammonium tetrathiomolybdate is developed; the ammonium tetrathiomolybdate can reduce the concentration of copper ions in the kidneys, reduces the activity of lysine oxidase, inhibits excessive crosslinking of extracellular matrixes, reduces the content of insoluble collagen, improves the fibrosis of the kidneys of rats, and provides a new treatment scheme for patients with renal interstitial fibrosis. Experimental results show that the ammonium tetrathiomolybdate can improve the fibrosis degree of the kidneys of rats and relieve deposition of kidney interstitial collagen. Therefore, the ammonium tetrathiomolybdate is indicated to be able to be used for preparing the medicine used for treating the renal interstitial fibrosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of ammonium tetrathiomolybdate in the preparation of medicine for treating renal interstitial fibrosis. Background technique [0002] There are more than 100 million patients with Chronic Kidney Disease (CKD) in China. With the increase of life expectancy and the rising incidence of cardiovascular disease and diabetes, the number of people who develop chronic kidney disease is increasing at an alarming rate. Yes, CKD patients eventually develop end-stage renal disease (End-Stage Renal Disease, ESRD), requiring life-long dialysis treatment, which brings a heavy burden to society and families. [0003] Renal interstitial fibrosis is a common pathological change that progresses from various CKDs to ESRD. The pathological basis of renal interstitial fibrosis is the massive accumulation of extracellular matrix (ECM), mainly including collagen and elastin. Then, the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61P13/12
CPCA61K33/24A61P13/12
Inventor 余晨牛阳阳朱赛雅张晓琴
Owner SHANGHAI TONGJI HOSPITAL
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