Blood-brain barrier drug delivery system and its preparation method and application
A delivery system and blood-brain barrier technology are applied in the field of cross-blood-brain barrier drug delivery system and its preparation, which can solve the problem of poor efficacy of glioma chemotherapy and achieve good drug delivery effect, easy operation, easy synthesis and controllability Effect
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Embodiment 1
[0032] Example 1: Preparation of polydopamine nanoparticles. Mix 3 milliliters of ammonia water, 40 milliliters of ethanol, and 90 milliliters of distilled water, and stir for 30 minutes at a temperature of 30 degrees Celsius and a magnetic stirrer speed of 500 rpm. After stirring, take 0.5 gram of dopamine hydrochloride and dissolve it in 10 milliliters of ultrapure water, and add it to the solution described in step 1), at a temperature of 30 degrees Celsius, a magnetic stirrer rotating speed of 500 rpm , reacted for 24 hours. After the reaction, centrifuge with a high-speed centrifuge (13800 rpm) and wash with water, repeating three times.
[0033] The polydopamine nanoparticles have a diameter of 176.24 nanometers and a potential of -51.5 millivolts.
Embodiment 2
[0034] Example 2: Preparation of polydopamine nanoparticles, 75 mg of dopamine hydrochloride was weighed and dissolved in 55 ml of ultrapure water, and 350 microliters of 1 mole per liter of sodium hydroxide solution was added dropwise to adjust the pH of the solution to 8.5. The mixture was reacted for 5 hours at a temperature of 45 degrees Celsius and a magnetic stirrer with a rotational speed of 500 rpm. After the reaction, centrifuge (13800 rev / min) with high-speed centrifuge and wash with water, repeat three times.
[0035] The polydopamine nanoparticles have a diameter of 135.34 nanometers and a potential of -30.9 millivolts.
Embodiment 3
[0036] Example 3: Preparation of polydopamine nanoparticles, 10 mg of dopamine hydrochloride was weighed and dissolved in 30 ml of 100 mmol / L tris buffer solution, the pH of the solution was controlled to be 8.5, and the reaction was carried out for 6 hours. After the reaction, centrifuge (13000-20000 revolutions per minute) and wash with water, repeat three times.
[0037] The polydopamine nanoparticles have a diameter of 160.83 nanometers and a potential of 22.8 millivolts.
[0038] figure 1 The particle size diagrams of polydopamine nanoparticles prepared in Experimental Examples 1-3 are shown; Examples 1-3 correspond to methods 1, 2, and 3, respectively.
[0039] Example 2 is the optimal example, and Example 2 is used as the preparation method of polydopamine nanoparticles to prepare highly efficient drug-loading composite nanomicelles for glioma:
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