Preparation method and application of polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and active hemostatic function

A technology of polyvinyl alcohol and porous materials, applied in the field of medical devices, can solve the problems of complex removal of residual reagents, toxic and side effects of final products, lack of cell adhesion function and active hemostasis, etc. High expansion performance and strong liquid absorption ability

Active Publication Date: 2020-05-08
安徽中科迈德医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these polyvinyl alcohol swelling sponges usually use formaldehyde or glutaraldehyde as a cross-linking agent and a large amount of acid as a catalyst in the preparation process, which may lead to a more complicated process of removing residual reagents during post-processing, and even affect the final product. Product brings toxic side effects
In addition, a single polyvinyl alcohol sponge can only rely on its own liquid absorption and compression capabilities to accelerate hemostasis, lacking cell adhesion and active hemostasis

Method used

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  • Preparation method and application of polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and active hemostatic function
  • Preparation method and application of polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and active hemostatic function
  • Preparation method and application of polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and active hemostatic function

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of a polyvinyl alcohol hemostatic sponge with high liquid absorption and high swelling performance and active hemostatic function, comprising the steps of:

[0030] (1) Disperse polyvinyl alcohol 2099 into dimethyl sulfoxide to form a suspension with a mass fraction of 10%; heat to 100°C, stir for 2 hours, and cool to room temperature; Bornene diacid anhydride, continue to stir and react for 24 hours; place it in a dialysis bag with a molecular weight cut-off of 3500, dialyze for 3 days, and freeze-dry;

[0031] (2) Disperse the product obtained in step (1) in distilled water to form a solution with a mass fraction of 20%; add 0.5% of the product obtained in step (1) with photoinitiator 2959, 20% mercapto with a weight average molecular weight of 2000 - Polyethylene glycol-mercapto, 1% gelatin, 0.5% sodium lauryl sulfate, vigorously stirred at 1500rpm for 30min for foaming, and the foamed material was exposed to a light intensity of 60 μW / cm 2 UV l...

Embodiment 2

[0034] A preparation method of a polyvinyl alcohol hemostatic sponge with high liquid absorption and high swelling performance and active hemostatic function, comprising the following steps:

[0035] (1) Disperse polyvinyl alcohol 2699 in dimethyl sulfoxide to form a suspension with a mass fraction of 10%; heat to 100°C, stir for 2 hours, and cool to room temperature; Bornene diacid anhydride, continue to stir and react for 24 hours; place it in a dialysis bag with a molecular weight cut-off of 3500, dialyze for 3 days, and freeze-dry;

[0036] (2) Disperse the product obtained in step (1) in distilled water to form a solution with a mass fraction of 30%; add photoinitiator 2959 with a mass fraction of 0.7% of the product obtained in step (1), and 20% mercapto with a weight average molecular weight of 2000 - Polyethylene glycol-mercapto, 1% gelatin, 0.5% sodium lauryl sulfate, vigorously stirred at 1500rpm for 30min for foaming, and the foamed material was exposed to light at ...

Embodiment 3

[0039] A preparation method of a polyvinyl alcohol hemostatic sponge with high liquid absorption and high swelling performance and active hemostatic function, comprising the following steps:

[0040](1) Disperse polyvinyl alcohol 2699 into dimethyl sulfoxide to form a suspension with a mass fraction of 20%; heat to 100°C, stir for 2 hours, and cool to room temperature; Bornene diacid anhydride, continue to stir and react for 24 hours; place it in a dialysis bag with a molecular weight cut-off of 3500, dialyze for 3 days, and freeze-dry;

[0041] (2) Disperse the product obtained in step (1) in distilled water to form a solution with a mass fraction of 30%; add 0.5% photoinitiator 2959 of the product obtained in step (1), 20% mercapto with a weight average molecular weight of 2000 - Polyethylene glycol-mercapto, 5% gelatin, 0.5% sodium lauryl sulfate, vigorously stirred at 1500rpm for 30min for foaming, and the foamed material was exposed to light at a light intensity of 60 μW / ...

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Abstract

The invention discloses a preparation method and application of a polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and an active hemostatic function. The hemostatic sponge prepared by the invention can be used for hemostasis of penetrating wounds and irregular incompressible wounds in an emergency site; the prepared polyvinyl alcohol hemostatic sponge does not adopt a traditional aldehyde group crosslinking mode; a large amount of concentrated acid catalyst is not added; therefore, tedious cleaning steps of post-treatment are avoided; theprepared sponge has high liquid absorption capacity and expansion performance, so that after the sponge is in contact with blood, a large amount of water in the blood can be absorbed to concentrate blood coagulation components, and the sponge can be quickly expanded in the liquid absorption process to achieve the effect of hemostasis by compression; meanwhile, due to the addition of an active hemostatic preparation, the blood coagulation effect of the sponge can be better improved, and the sponge has good biocompatibility, high liquid absorption capacity and expansibility, excellent hemostaticeffect and the like, and has a wide clinical application prospect.

Description

technical field [0001] The invention specifically relates to the technical field of medical devices, in particular to a preparation method and application of a polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and active hemostatic function. Background technique [0002] At the scene of first aid, special parts of the wounded body, such as limb joints or joint joints (joints, armpit, groin, subfascial space, etc.), have a high probability of being injured. Rupture, forming pulsatile or projecting hemorrhages, in addition to bleeding from deep, irregular, and incompressible wounds caused by small-caliber firearms or explosions in battlefields, traffic accidents, and everyday life. This type of bleeding is often uncontrollable with traditional hemostasis. Therefore, effective resolution of this type of hemorrhage has the potential to be an important goal in the next development of trauma resuscitation. [0003] High swell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J9/04C08J3/24C08L51/00C08L89/00C08F261/04C08F232/08A61L24/00A61L24/02A61L24/06A61L24/08A61L24/10
CPCA61L24/001A61L24/0015A61L24/0036A61L24/02A61L24/06A61L24/08A61L24/104A61L24/106A61L24/108A61L2400/04C08F261/04C08J3/24C08J9/0033C08J9/04C08J9/28C08J2351/00C08J2489/00C08L51/00C08F232/08
Inventor 石长灿杨啸刘雯席光辉李徐坚季志孝
Owner 安徽中科迈德医疗科技有限公司
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