Anesthetic analysis method

An analysis method and anesthetic technology, applied in the field of analysis and testing, can solve the problems of difficult automatic operation, secondary pollution, long time consumption, etc., and achieve the effect of good separation effect, good accuracy, and avoiding the reduction of signal-to-noise ratio.

Pending Publication Date: 2020-05-08
上海微谱检测科技集团股份有限公司
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its advantage is simple operation, but there are also disadvantages such as large consumption of organic solvents, secondary pollution to the environment, long time consumption, low recovery rate, serious emulsification phenomenon, and difficulty in automatic operation.

Method used

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Embodiment 1

[0065] Embodiment 1 of the present invention provides a kind of analytical method of anesthetic, comprises the following steps:

[0066] (1) Solution preparation;

[0067] (2) Sample test;

[0068] (3) Performance verification;

[0069] Said solution preparation comprises five steps of configuration of linear solution, configuration of sample mother solution, configuration of sample solution, configuration of limit of quantitation solution, configuration of accuracy solution and configuration of repeatability solution;

[0070] The preparation process of described linear solution is: get DBP reference substance mother liquor, and use compound solvent constant volume, according to Table 6 linear solution, each target object linear concentration sees Table 7, wherein the concentration of DBP reference substance mother liquor is 10mg / L; The compound solvent mentioned above is ethyl acetate and n-hexane, and the corresponding weight ratio is 2.2:2.8.

[0071] Table 6 Linear sol...

Embodiment 2

[0094] Embodiment 2 of the present invention provides a kind of detection method of dibutyl phthalate in alfentanil hydrochloride, its specific implementation is the same as embodiment 1, the difference is that the configuration process of the sample solution is to take the sample mother liquor Put 20mL in the analysis bottle, add 5mL of n-hexane, mix well, and let stand; separate the organic phase, add anhydrous magnesium sulfate, and then take the supernatant;

Embodiment 3

[0096] Embodiment 3 of the present invention provides a detection method for dibutyl phthalate in alfentanil hydrochloride, its specific implementation is the same as in Embodiment 1, the difference is that the configuration process of the sample solution is to take the sample mother liquor 20mL in the analytical bottle, add 5mL of compound solvent, mix well, and let stand; separate the organic phase, add anhydrous magnesium sulfate, and then take the supernatant; the compound solvent is ethyl acetate and n-hexane, the corresponding weight The portion ratio is 4:1.

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Abstract

The invention provides an anesthetic analysis method. The anesthetic analysis method comprises the following steps of: (1) solution preparation; (2) sample testing; and (3) performance verification; wherein the solution preparation comprises five steps of: preparation of a linear solution, preparation of a sample mother solution, preparation of a sample solution, preparation of a quantitation limit solution and preparation of an accuracy solution. The anesthetic analysis method has good accuracy, can still separate different substances at a higher heating rate, reaches a good separation effect, and avoids the situations that a signal-to-noise ratio is reduced, the relative standard deviation is increased and the like. The method can be used as a test method for determining the DBP in a ropivacaine hydrochloride process liquid in the biological medicine business division.

Description

technical field [0001] The invention relates to the field of analysis and testing, in particular to an analysis method for anesthetics. Background technique [0002] Ropivacaine is a long-acting amide local anesthetic. Its pharmacological properties are low cardiotoxicity, more obvious separation of sensory block and motor block, and vasoconstriction. Ropivacaine has dual effects of anesthesia and analgesia, and is suitable for surgical anesthesia, epidural anesthesia, postoperative analgesia, and 72-hour local anesthesia during childbirth. It can effectively block sensory nerve transmission and produce analgesic effect. It has little effect on motor nerves. The product was first developed by Astra Company of Sweden in 1994, and Ropivacaine Hydrochloride Injection was approved for marketing in the United States in 1995. [0003] Phthalic acid esters (PAEs) are an important class of endocrine disruptors. Trace amounts of PAEs will be enriched in water, soil, animals and pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88
Inventor 贾梦虹吴杰李志坤
Owner 上海微谱检测科技集团股份有限公司
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