Self-repairing hydrogel synthesized through autocatalysis, preparation method of gel precursor of the self-repairing hydrogel, and synthesis method of hydrogel

Abstract

The invention relates to the technical field of hydrogel preparation, in particular to self-repairing hydrogel synthesized through autocatalysis, a preparation method of a gel precursor of the self-repairing hydrogel, and a synthesis method of the hydrogel. Polyethylene glycol dicyanoacetate and polyamino polyaldehyde are used as precursors, and active methylene provided by polyethylene glycol dicyanoacetate, aldehyde provided by polyamino polyaldehyde and a catalyst tertiary amine are subjected to a Knoevenagel condensation reaction to form the self-repairing hydrogel in situ. As the gel precursor provides tertiary amine as a catalyst for a Knoevenagel condensation reaction, the Knoevenagel condensation reaction can be carried out in one step; the preparation of the hydrogel does not needadditional addition of a catalyst or ultraviolet irradiation; according to the present invention, the prepared hydrogel has characteristics of self-catalysis and substantially improved biocompatibility, does not require the additional addition of the catalyst, and is formed by the dynamic C=C bond cross-linking in the self-catalysis environment, such that the obtained hydrogel has good self-repair ability, and can rapidly self-heal after the hydrogel is subjected to external damage.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a method for preparing a self-repairing hydrogel synthesized by self-catalysis and a gel precursor thereof, and a method for synthesizing the hydrogel. Background technique [0002] Hydrogels are a class of cross-linked polymers with a three-dimensional network structure, which have a large number of hydrophilic groups or domains. These networks have a high affinity for water and have many features similar to extracellular matrix. In recent years, due to their good biocompatibility, they have been widely studied and applied in various biomedical applications (tissue engineering, drug delivery, wound healing, Cell culture, etc.), flexible electronics, bionics. [0003] In situ shaped hydrogels exhibit low viscosity in the sol state, can fill defects of any shape, and allow the uniform incorporation of therapeutic molecules and / or cells without surgical procedures, at...

AI Technical Summary

Problems solved by technology

However, most of the existing in situ forming hydrogel systems require ultraviolet light irradiation or the addition of catalysts, which reduces the biocompatibility of the gel to some extent.

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