Composition of beta-nicotinamide mononucleotide or beta-nicotinamide mononucleotide precursor, and preparation method and application of composition

A single nucleotide, nicotinamide ribose technology, applied in the field of biomedicine, can solve the problems of difficult penetration of macromolecular substances into the skin, no research and reports, etc., to improve the internal function of the human body, maintain blood drug concentration, and improve the The effect of epidermal function

Inactive Publication Date: 2020-05-19
浙江安赛新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The skin is a natural barrier that can resist the invasion of foreign substances. It is difficult for macromolecular substances to penetrate the skin. Therefore, the drug made into percutaneous absorption generally requires a molecular weight of less than 500-1000. The molecular weight of β-nicotinamide mononucleotide is 334.22 , although it is just in the range that can be absorbed through the skin, so far, whether it can be absorbed through the skin has not been reported. In the past, the administration of NMN was completed by injection or oral administration. The administration route and effect, as well as the improvement of the overall function of the human body and the skin itself by external administration have not yet been studied and reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Spray

[0034] Composition: β-nicotinamide mononucleotide 1wt%, propylene glycol 5wt%, sodium benzoate 0.2wt%, deionized water 93.8wt%.

[0035] Preparation method: mix deionized water and propylene glycol, stir and heat to 80 ° C, hold for 15 minutes, cool down to 35 ° C, add β-nicotinamide mononucleotide and sodium benzoate, stir until completely dissolved, cool to 25 ° C, tank Fill into a suitable spray container.

Embodiment 2

[0036] Example 2: Water agent

[0037] Composition: β-nicotinamide mononucleotide 5wt%, propylene glycol 10% water-soluble azone 2wt%, sodium hyaluronate 0.2wt%, sorbic acid 0.1wt%, and the balance is deionized water.

[0038] Preparation method: mix deionized water and propylene glycol, stir and heat to 80 ° C, add sodium hyaluronate and stir until dissolved, keep for 15 minutes, cool down to 35 ° C, add β-nicotinamide mononucleotide, water-soluble azone and Sorbic acid, stirring until completely dissolved, canned into a suitable container.

[0039] Example Column 3: Gel

[0040] Composition: β-nicotinamide mononucleotide 15wt%, propylene glycol 10wt%, water-soluble azone 2wt%, sodium hyaluronate 0.1wt%, carbo (polyacrylic acid) 0.3wt%, triethanolamine 0.25wt%, sodium benzoate 0.2wt%, the balance is deionized water.

[0041] Preparation method: stir deionized water, add sodium hyaluronate, heat to 80 ° C, stir until completely dissolved; mix propylene glycol and carbomer, ...

experiment example 1

[0051] Experimental Example 1: Relief effect of percutaneously inhaled preparation on fatigue

[0052] Five fatigue patients were treated with the 20wt% β-nicotinamide mononucleotide cream ointment obtained in Example 5. Use the cream twice a day, apply 3-5 grams to the face, hands and forearms each time, massage slowly after use until fully absorbed. The test time was four weeks. The results showed that one of the five testers had no obvious feeling, and the remaining four felt symptoms of varying degrees of relief within three weeks.

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PUM

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Abstract

The invention relates to the field of biological medicines, and in particular to a composition of beta-nicotinamide mononucleotide or a beta-nicotinamide mononucleotide precursor, and a preparation method and application of the composition. The composition comprises the following raw materials in percentage by weight: 0.001 to 25 percent of beta-nicotinamide mononucleotide or a precursor thereof,0 to 20 percent of a transdermal absorption enhancer, 2 to 50 percent of an auxiliary component and the balance of water. After being absorbed by a human body in a mode of transdermal administration or external administration, the composition can exert effects of improving internal functions of a human body, improving metabolism of a human body or improving epidermal functions of a human body, andresisting skin inflammation, allergy and skin aging. Through the mode of transdermal administration and external administration, metabolic burden of liver and kidney can be avoided, blood concentration can be kept constant, and administration is convenient.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a composition, preparation method and application of beta-nicotinamide mononucleotide (NMN, nicotinamide mononucleotide) or its precursor beta-nicotinamide riboside (NR, nicotinamide riboside). Background technique [0002] With the increase of age, the body gradually appears the decline of the physiological function resistance and adaptability of cells, tissues and organs. The overall and skin function of the human body gradually decreases with the increase of the body's age, which leads to aging, and the incidence of various internal and external diseases related to it increases. The basis of body aging. [0003] As the body ages, one of the most significant changes in the body's cells is the decrease in the level of NAD+, thus linking the decrease in the level of NAD+ with various internal and external diseases related to aging. NAD+ is also called coenzyme I, the full n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K9/00A61P17/18A61P17/00A61P3/00
CPCA61K9/0014A61K31/706A61P3/00A61P17/00A61P17/18
Inventor 尹玉岭徐青侯杰
Owner 浙江安赛新材料科技有限公司
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