Camellia oil-contained skin barrier repairing micro-nano emulsion and preparation method therefor

A technology of skin barrier repair and micro-nano emulsion, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of poor skin permeability, uneven active ingredients, and poor effects, and achieve Repairs the skin barrier, excellent affinity, and excellent skin care effect

Pending Publication Date: 2020-05-22
HANGZHOU QIANDAOHU TIANXIN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to solve the problems of existing skin/stratum corneum barrier repair emulsions, such as uneven active ingredients, poor water solubility and easy precipitation, or problems such as poor compatibility and poor skin permeability, or problems such as st

Method used

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  • Camellia oil-contained skin barrier repairing micro-nano emulsion and preparation method therefor
  • Camellia oil-contained skin barrier repairing micro-nano emulsion and preparation method therefor
  • Camellia oil-contained skin barrier repairing micro-nano emulsion and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Prepare 1kg skin barrier repairing micro-nano emulsion containing camellia oil;

[0075] Its ingredients are as follows:

[0076] Camellia oil (200g), ceramide 2 (10g), cholesterol (6g), stearic acid (4g), water (20g), lecithin (30g), glycerin (730g);

[0077] The preparation method is as follows:

[0078] 1-a) Mix glycerin with water, add lecithin and homogenize at 63±2°C until the phospholipids swell uniformly, as phase A;

[0079] 1-b) Mix ceramide 2, cholesterol, stearic acid and camellia oil, stir at 78±2°C until ceramide, cholesterol and fatty acid are all dissolved to form a uniform oil phase, then cool down to 64±1°C for storage as Phase B;

[0080] 2) Mix Phase A and Phase B for 5000rpm high-speed homogenization for 5 minutes. After high-speed homogenization, a pretreatment solution is obtained. The pretreatment solution is subjected to high-pressure homogenization by a micro-jet high-pressure homogenizer, and the homogenization pressure is set to 200MPa. Cy...

Embodiment 2

[0083] Prepare 1kg skin barrier repairing micro-nano emulsion containing camellia oil;

[0084] Its ingredients are as follows:

[0085] Camellia oil (250g), ceramide 3 (25g), cholesterol (12.5g), oleic acid (7.5g), water (50g), hydrogenated lecithin (40g), glycerin (615g);

[0086] The preparation method is as follows:

[0087] 1-a) Mix glycerin and water, add hydrogenated lecithin and homogenize at 63±2°C until the phospholipids swell uniformly, as phase A;

[0088] 1-b) Mix ceramide 3, cholesterol, oleic acid and camellia oil, stir at 78±2°C until ceramide, cholesterol and fatty acid are all dissolved to form a uniform oil phase, then cool down to 64±1°C for storage as Phase B;

[0089] 2) Mix Phase A and Phase B for 6000rpm high-speed homogenization for 8 minutes. After high-speed homogenization, a pretreatment solution is obtained. The pretreatment solution is subjected to high-pressure homogenization by a micro-jet high-pressure homogenizer, and the homogenization press...

Embodiment 3

[0092] Prepare 1kg skin barrier repairing micro-nano emulsion containing camellia oil;

[0093] Its ingredients are as follows:

[0094] Camellia oil (400g), ceramide 3 (20g), ceramide 2 (20g), cholesterol (20g), palmitic acid (10g), linoleic acid (4g), water (100g), lecithin (50g), glycerin (376g);

[0095] The preparation method is as follows:

[0096] 1-a) Mix glycerin with water, add lecithin and homogenize at 63±2°C until the phospholipids swell uniformly, as phase A;

[0097] 1-b) Mix ceramide 2, ceramide 3, cholesterol, palmitic acid, linoleic acid and camellia oil, stir at 78±2°C until ceramide, cholesterol and fatty acid are all dissolved to form a uniform oil phase, then cool down Store at 64±1°C as phase B;

[0098] 2) Mix Phase A and Phase B and perform high-speed homogenization at 6000rpm for 10 minutes. After high-speed homogenization, a pretreatment solution is obtained. The pretreatment solution is subjected to high-pressure homogenization by a micro-jet hi...

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Abstract

The invention relates to the field of cosmetics, in particular to a camellia oil-contained skin barrier repairing micro-nano emulsion and a preparation method therefor. The skin barrier repairing micro-nano emulsion comprises the following ingredients, 10-50 wt% of camellia oil, 0.1-5 wt% of ceramide, 0.05-3 wt% of cholesterol, 0.03-2 wt% of fatty acid, 1-10 wt% of water, 1-10 wt% of phospholipidand the balance glycerin; the preparation method comprises the following steps of mixing the glycerin with the water, and adding the phospholipid and performing uniform swelling to obtain a phase A; mixing the ceramide with the cholesterol, the fatty acid and the camellia oil, and performing stirring until solutes dissolve to obtain a phase B; and mixing and homogenizing the phase A and the phaseB to obtain a pretreatment solution, performing high-pressure homogenization on the pretreatment solution, and performing discharging and cooling to obtain the camellia oil-contained skin barrier repairing micro-nano emulsion. The nano emulsion prepared by the preparation method has a good skin barrier repairing effect, and has a faster repairing rate; and the entire emulsion has high stability and water dispersibility, and is conveniently matched and mixed with the remaining components.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a skin barrier repair micro-nano emulsion containing camellia oil and a preparation method thereof. Background technique [0002] The skin barrier function is one of the important functions of the skin. Excessive cleaning, makeup removal, and some sensitive skin will weaken the skin barrier. The lipids in the stratum corneum are very important for the normal function of the skin barrier. Skin problems such as dryness and roughness are the external manifestations of stratum corneum dysfunction. At this time, simply adding moisture to the skin cannot change the dry state of the skin, and more importantly, replenishing the lipids of the stratum corneum The ingredients achieve restoration and maintenance of normal stratum corneum barrier function. [0003] The lipids that constitute the human skin barrier mainly include two parts: the sebum membrane and the intercellular lipids of the stra...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/36A61K8/55A61K8/63A61K8/68A61K8/06A61Q19/00
CPCA61K8/922A61K8/68A61K8/63A61K8/553A61K8/068A61K8/361A61Q19/00A61K2800/21A61K2800/592
Inventor 唐礼荣邓学阳董全喜
Owner HANGZHOU QIANDAOHU TIANXIN CO LTD
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